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Effect of interleukin-2 level and genetic variants on coronary artery disease

文献类型： 外文期刊

作者： Ding, Ru 1 ; Gao, Wenwu 2 ; Ostrodci, David H. 3 ; He, Zhiqing 1 ; Song, Yuanlin 4 ; Ma, Lan 5 ; Liang, Chun 1 ; Wu, Zong 1 ;

作者机构： 1.Second Mil Med Univ, Changzheng Hosp, Dept Cardiol, Shanghai 200003, Peoples R China

2.Shanghai Univ Tradit Chinese Med, Putuo Hosp, Dept Orthoped, Shanghai 200062, Peoples R China

3.NYU, Fac Med, New York, NY 10011 USA

4.Shandong Acad Agr Sci, Jinan 250100, Shandong, Peoples R China

5.Tongji Univ, Shanghai East Hosp, Dept Cardiol, Shanghai 200120, Peoples R China

关键词： coronary artery disease;Interleukin-2;polymorphism;serum level

期刊名称：INFLAMMATION （ 影响因子：4.092； 五年影响因子：3.923 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Inflammation plays important roles in the development of atherosclerosis and coronary artery disease (CAD). Interleukin-2 (IL-2) is a proinflammatory cytokine and induces proliferation of T cells. The aim of the study was to understand the effect of IL-2 on the development of CAD from genetic polymorphism perspective and serum level perspective. IL-2 -330T/G and +114T/G polymorphisms were tested in 692 CAD cases and 723 healthy controls. IL-2 expression of these two polymorphisms was compared. Serum level of IL-2 in CAD patients and controls was analyzed. Data showed that prevalence of IL-2 -330GG genotype was significantly increased in CAD than in controls (p = 5.1 × 10-6). Function analysis revealed that subjects carrying IL-2 -330GG genotype had higher serum level of IL-2 than those with TG or TT genotypes (p < 0.01). Serum level of IL-2 in the study subjects was further analyzed, and results showed that CAD patients had significantly increased IL-2 level than healthy controls (p < 0.01). Also, cases with three vessels affected were observed to have higher IL-2 level than cases with one vessel affected (p < 0.05). These data suggested IL-2 polymorphism could affect the susceptibility to CAD by elevating protein expression, and serum level of IL-2 may be closed correlated with the development and progression of this disease.

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