文献类型： 外文期刊
作者： Yue, Hong-Wei 1 ; Jing, Qing-Chuan 2 ; Liu, Ping-Ping 3 ; Liu, Jing 1 ; Li, Wen-Jing 1 ; Zhao, Jing 1 ;
作者机构： 1.Shandong Univ, Sch Life Sci, Shandong Prov Key Lab Anim Cells & Dev Biol, Jinan 250100, Peoples R China
2.Shandong Acad Agr Sci, Inst Poultry Sci, Jinan 250023, Peoples R China
3.Binzhou Med Univ, Dept Cardiol, Affiliated Hosp, Yantai 264000, Peoples R China
关键词： Sphingosylphosphorylcholine;second messenger;GPCRs;cancer
期刊名称：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE （ 影响因子：0.166； 五年影响因子：0.621 ）
ISSN： 1940-5901
年卷期： 2015 年 8 卷 8 期
页码：
收录情况： SCI
摘要： Sphingosylphosphorylcholine (SPC) is a naturally occurring bioactive sphingolipid in blood plasma, metabolizing from the hydrolysis of the membrane sphingolipid. It has been shown to exert multifunctional role in cell physiological regulation either as an intracellular second messenger or as an extracellular agent through G protein coupled receptors (GPCRs). Because of elevated levels of SPC in malicious ascites of patients with cancer, the role of SPC in tumor progression has prompted wide interest. The factor was reported to affect the proliferation and/or migration of many cancer cells, including pancreatic cancer cells, epithelial ovarian carcinoma cells, rat C6 glioma cells, neuroblastoma cells, melanoma cells, and human leukemia cells. This review covers current knowledge of the role of SPC in tumor.
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