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Nutrient Intake Is Associated with Longevity Characterization by Metabolites and Element Profiles of Healthy Centenarians

文献类型： 外文期刊

作者： Cai, Da 1 ; Zhao, Shancang 2 ; Li, Danlei 3 ; Chang, Fang 4 ; Tian, Xiangxu 4 ; Huang, Guohong 1 ; Zhu, Zhenjun 1 ; Liu, 1 ;

作者机构： 1.Guangxi Univ, Coll Light Ind & Food Engn, Nanning 530004, Peoples R China

2.Shandong Acad Agr Sci, Inst Agr Qual Stand & Testing Technol Res, Jinan 250100, Peoples R China

3.Tianjin Normal Univ, Coll Life Sci, Tianjin 300387, Peoples R China

4.Jinan Acad Agr Sci, Inst Agroprod Qual Testing, Jinan 250316, Peoples R China

5.Guangxi Polytech Coll, Food & Biol Technol Dept, Nanning 530226, Peoples R China

6.Harvard Med Sch, Dept Neurol, Vet Affairs Boston Healthcare Syst, West Roxbury, MA 02132 USA

关键词： centenarian;nutrient intake;metabolite;element;longevous region;pattern recognition;partial least squares-discriminant analysis

期刊名称：NUTRIENTS （ 影响因子：5.717； 五年影响因子：6.349 ）

ISSN： 2072-6643

年卷期： 2016 年 8 卷 9 期

页码：

收录情况： SCI

摘要： The relationships between diet and metabolites as well as element profiles in healthy centenarians are important but remain inconclusive. Therefore, to test the interesting hypothesis that there would be distinctive features of metabolites and element profiles in healthy centenarians, and that these would be associated with nutrient intake; the short chain fatty acids (SCFAs), total bile acids and ammonia in feces, phenol, p-cresol, uric acid, urea, creatinine and ammonia in urine, and element profiles in fingernails were determined in 90 healthy elderly people, including centenarians from Bama county (China)a famous longevous regionand elderly people aged 80-99 from the longevous region and a non-longevous region. The partial least squares-discriminant analysis was used for pattern recognition. As a result, the centenarians showed a distinct metabolic pattern. Seven characteristic components closely related to the centenarians were identified, including acetic acid, total SCFA, Mn, Co, propionic acid, butyric acid and valeric acid. Their concentrations were significantly higher in the centenarians group (p < 0.05). Additionally, the dietary fiber intake was positively associated with butyric acid contents in feces (r = 0.896, p < 0.01), and negatively associated with phenol in urine (r = -0.326, p < 0.01). The results suggest that the specific metabolic pattern of centenarians may have an important and positive influence on the formation of the longevity phenomenon. Elevated dietary fiber intake should be a path toward health and longevity.

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[1]A Correlation Between Diet and Longevity Characterization by Means of Element Profiles in Healthy People over 80 Years from a Chinese Longevous Region. Cai, Da,Wang, Fang,Huang, Guohong,Zhao, Mouming,Li, Quanyang,Li, Danlei,Zhao, Shancang,Dou, Xiaowei.

[2]Determination of Mesotrione and Its Metabolite Residues in Maize by Ultra Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry. Deng Li-Gang,Lu Fu-Sui,Deng Li-Gang,Li Zeng-Mei,Zhao Shan-Cang,Chen Ye-Bing,Guo Chang-Ying,Deng Li-Gang,Li Zeng-Mei,Zhao Shan-Cang,Chen Ye-Bing,Guo Chang-Ying. 2013

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