Potential Pathways Involved in Elaidic Acid Induced Atherosclerosis in Human Umbilical Vein Endothelial Cells
文献类型： 外文期刊
作者： Yu, Huahong 1 ; Li, Xiangmei 1 ; Liang, Zhongshang 1 ; Qiu, Bin 2 ; Li, Siguang 3 ; Luo, Ting 1 ; Li, Jing 1 ; Li, Hongya 1 ;
作者机构： 1.Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang, Jiangxi, Peoples R China
2.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Jinan 250100, Peoples R China
3.Tongji Univ, Tongji Hosp, Stem Cell Translat Res Ctr, Sch Med, Shanghai 200065, Peoples R China
期刊名称：JOURNAL OF CHEMISTRY （ 影响因子：2.506； 五年影响因子：2.726 ）
ISSN： 2090-9063
年卷期： 2017 年
页码：
收录情况： SCI
摘要： Researches have demonstrated that trans-fatty acids are related to the progression of atherosclerosis, but the underlying mechanism is not clear till now. In the presented study, two-dimensional electrophoresis based proteomics was used to discover the role of elaidic acid in atherosclerosis. In human umbilical vein endothelial cells (HUVEC), twenty-two and twenty-three differentially expressed proteins were identified in low (50 mu mol/L) and high (400 mu mol/L) concentration elaidic acid simulated groups, respectively, comparing with the control group. The expressions of some selected proteins (PSME3, XRCC5, GSTP(1), andGSTO(1)) were validated by qRT-PCR analysis. Western blotting analysis further confirmed that elaidic acid downregulated the expression of PSME3 and XRCC5. Moreover, P53, the downstream protein of PSME3, was further investigated. Results demonstrated that a variety of proteins, many of which were related to oxidative stress, apoptosis, and DNA damage, were involved in the elaidic acid induced atherosclerosis. Furthermore, P53 was demonstrated to regulate the atherosclerosis through cell cycle arrest and apoptosis pathway.
- 相关文献
作者其他论文 更多>>
-
Liposome-lentivirus for miRNA therapy with molecular mechanism study
作者：Sun, Fen;Sun, Fen;Chen, Huaqing;Dai, Xiaoyong;Li, Jing;Huang, Laiqiang;Chen, Huaqing;Hou, Yibo;Li, Jing;Huang, Laiqiang;Dai, Xiaoyong;Zhang, Yinghe;Guo, Bing;Guo, Bing;Yang, Dongye
关键词：LCSCs; miR-145-5p; Autophagy; GSK3 beta/Wnt/beta-catenin
-
Encapsulation of Lactobacillus plantarum in W1/O/W2 double emulsions stabilized with the high-intensity ultrasound-treated pea protein and pectin
作者：Zhang, Chao;Zhang, Yu;Qiu, Bin;Zhang, Nan;Liu, Xia;Qi, Shasha;Liu, Wei;Zhang, Chao;Zhang, Nan;Li, Lingfei;Liu, Zhenhua;Gao, Xueyan
关键词：W1/O/W2 emulsion; Pea protein; Ultrasound treatment; Lactobacillus plantarum; Pectin; In-vitro simulated gastrointestinal digestion
-
The hidden indirect environmental effect undercuts the contribution of crop nitrogen fertilizer application to the net ecosystem economic benefit
作者：Yang, Quanfeng;Zheng, Hua;Gong, Huarui;Li, Jing;Qiao, Fei;Zhang, Kening;Ouyang, Fang;Ge, Feng;Ma, Junhua;Li, Jing;Men, Xingyuan;Ge, Feng;Lu, Zengbin;Yang, Fei;Zheng, Hua;Ouyang, Fang
关键词：Sustainable crop production; Crop excessive N fertilizer application; N-Crop-pest cascade pathway; Chemical pesticide; Net ecosystem economic benefit (NEEB); Cereal aphid
-
Characterization and complete genome sequence analysis of a newly isolatedphage against Vibrio parahaemolyticus from sick shrimp in Qingdao, China
作者：Tian, Fengjuan;Li, Jing;Hu, Yunjia;Li, Fei;Tong, Yigang;Zhao, Feiyang;Ren, Huiying;Pan, Qiang;Nazir, Amina;Li, Fei
关键词：
-
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism
作者：Zhang, Di;Liu, Xia;Zhang, Yuhan;Xiang, Guo;Yu, Meng;Li, Xin-gang;Zhang, Di;Zhang, Yuhan;Li, Xin-gang;Cui, Yi;Zhang, Di;Li, Xin-gang;Liu, Wei;Liu, Xia;Wang, Xianshu;Qiu, Bin;Liu, Wei;Zhang, Di
关键词：Melatonin; Gut microbiota; Akkermansia; Ventral tegmental area
-
The Preventive Effects of Fermented and Germinated Foxtail Millet Whole Grain on Kidney Damage in a Diabetic Mouse Model
作者：Liu, Xia;Zhang, Di;Liu, Xia;Qiu, Bin;Liu, Wei;Wang, Xianshu;Liu, Wei;Zhang, Yuhan;Li, Xingang;Zhang, Di;Li, Xingang;Zhang, Di;Li, Lingfei
关键词：foxtail millet; fermentation; germination; diabetic kidney disease; gut microbiota
-
Therapeutic and Prebiotic Effects of Five Different Native Starches on Dextran Sulfate Sodium-Induced Mice Model of Colonic Colitis
作者：Xu, Zhenzhen;Liu, Wei;Zhang, Yuhan;Qiu, Bin;Wang, Xianshu;Liu, Lina;Zhang, Di;Liu, Jie
关键词：gut microbiota; inflammatory bowel disease; mouse colitis model; native starches; prebiotic
