The Preventive Effects of Fermented and Germinated Foxtail Millet Whole Grain on Kidney Damage in a Diabetic Mouse Model
文献类型： 外文期刊
作者： Liu, Xia 1 ; Qiu, Bin 2 ; Liu, Wei 2 ; Zhang, Yuhan 3 ; Wang, Xianshu 2 ; Li, Xingang 3 ; Li, Lingfei 5 ; Zhang, Di 1 ;
作者机构： 1.Shandong Univ, Cheeloo Coll Med, Med Integrat & Practice Ctr, Jinan, Peoples R China
2.Shandong Acad Agr Sci, Jinan, Peoples R China
3.Jinan Microecol Biomed Shandong Lab, Jinan, Peoples R China
4.Shandong Univ, Qilu Hosp, Dept Neurosurg, Jinan, Peoples R China
5.Yunnan Agr Univ, Coll Food Sci & Technol, Kunming, Peoples R China
关键词： foxtail millet; fermentation; germination; diabetic kidney disease; gut microbiota
期刊名称：FRONTIERS IN NUTRITION （ 影响因子：6.59； 五年影响因子：6.873 ）
ISSN： 2296-861X
年卷期： 2022 年 9 卷
页码：
收录情况： SCI
摘要： Diabetic kidney disease (DKD) is an important complication of diabetes. The prevention of DKD can effectively reduce the mortality rate of diabetic patients and improve their quality of life. The present study examined the effects of fermented and germinated foxtail millet whole grain (FG-FM) on kidney lesions in a diabetic mouse model (Db/Db mice). The results proved that the FG-FM consumption significantly alleviated the kidney tissue damage in the diabetic mouse model. The transcriptome analysis of kidney tissues demonstrated that the overactivation of signaling pathways related to inflammation and immunity in the diabetic mouse model was significantly inhibited with the FG-FM intake. Moreover, the consumption of the FG-FM diet effectively elevated the bacterial diversity, increased the relative abundance of probiotics and decreased the relative abundance of previously reported DKD-related bacteria in the gut microbiota of diabetic mice. Our study confirmed foxtail millet as a potential source of functional food for the non-pharmacological intervention of DKD.
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