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A missense mutation of the WNK1 gene affects cold tolerance in Chinese domestic cattle

文献类型： 外文期刊

作者： Liu, Xin 1 ; Chen, Jialei 1 ; Xu, Xinlong 1 ; Liu, Jianyong 2 ; Zhang, Jicai 2 ; Cheng, Haijian 3 ; Ahmed, Zulfiqar 4 ; Huang, Bizhi 2 ; Lei, Chuzhao 1 ;

作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod Shaanxi Prov, Yangling, Peoples R China

2.Yunnan Acad Grassland & Anim Sci, Kunming, Peoples R China

3.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Shandong Key Lab Anim Dis Control & Breeding, Jinan, Peoples R China

4.Univ Poonch Rawalakot Azad Jammu & Kashmir Pakista, Fac Vet & Anim Sci, Rawalakot, Pakistan

5.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling, Peoples R China

关键词： Chinese domestic cattle; cold tolerance; with-no-lysine kinases 1 (WNK1); single nucleotide polymorphisms (SNP)

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：3.7； 五年影响因子：3.3 ）

ISSN： 1049-5398

年卷期： 2023 年

页码：

收录情况： SCI

摘要： Inclement weather conditions, especially cold stress, have threatened the cattle industry. Cattle exposed to cold environments for a longer time suffer developmental delay, immunity decline, and eventually death. WNK1 is a member of With-no-lysine kinases (WNKs), widely expressed in animal organs and tissues. WNK1 and WNK4 are expressed in adipose tissue, and WNK4 promotes adipogenesis. WNK1 does not directly affect adipogenesis but has been shown to promote WNK4 expression in several tissues or organs. One missense mutation NC_037346.1:g.107692244, A > G, rs208265410 in the WNK1 gene was detected from the database of bovine genomic variation (BGVD). Here, we collected 328 individuals of 17 breeds representing four groups of Chinese cattle, northern group cattle, southern group cattle, central group cattle, and special group cattle (Tibetan cattle). We also collected the temperature and humidity data records from their relative locations. The frequencies of the G allele in Chinese breeds increased from northern China to southern China, and the frequencies of the A allele showed an opposite trend. Our results indicate that the WNK1 gene might be a candidate gene marker associated with cold tolerance.

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