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Classification and structural insight into vibriolysin-like proteases of Vibrio pathogenicity

文献类型： 外文期刊

作者： Huang, JiaFeng 1 ; Zeng, BingQi 1 ; Liu, Dan 1 ; Wu, RiBang 1 ; Zhang, Jiang 1 ; Liao, BinQiang 1 ; He, HaiLun 1 ; Bian, Fei 2 ;

作者机构： 1.Cent S Univ, Sch Life Sci, State Key Lab Med Genet, Changsha 410013, Hunan, Peoples R China

2.Shandong Acad Agr Sci, Biotechnol Res Ctr, Jinan 250000, Shandong, Peoples R China

关键词： Vibrio; Vibriolysin-like proteases (VLPs); Phylogenetic tree; Classification; Structure; Vibrio pathogenicity

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.663 ）

ISSN： 0882-4010

年卷期： 2018 年 117 卷

页码：

收录情况： SCI

摘要： Vibriolysin-like proteases (VLPs) are important virulence agents in the arsenal of Vibrio causing instant cytotoxic effects during infection. Most of Vibrio secreted VLPs show serious pathogenicity, while some species of Vibrio with VLPs are non-pathogenic, like Vibrio tasmaniensis and Vibrio pacinii. To investigate the relation between VLPs and Vibrio pathogenicity, one phylogenetic tree of VLPs was constructed and compared consensus sequences at the N-terminus of VLPs. Based on these results, VLPs were defined into nine phylogenetic clades. Pathogenicity analysis of Vibrio showed that Vibrio species with VLPs III, VI, VII or VIII are serious pathogenic bacteria, while species with VLPs I, II, IV or IX are opportunistic pathogens. Multiple sequence alignment showed that the N-terminal 5-16 nucleotides of each Glade are highly conservative. Topological analysis of VLPs exhibited the structural differences in N-terminal regions of each VLP Glade. These results suggest that structure of N-terminus might play a key role in the pathogenicity of VLPs. Our findings give new insights into the classification of VLPs and the relationship between VLPs and Vibrio pathogenicity.

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[1]Classification and structural insight into vibriolysin-like proteases of Vibrio pathogenicity. Huang, JiaFeng,Zeng, BingQi,Liu, Dan,Wu, RiBang,Zhang, Jiang,Liao, BinQiang,He, HaiLun,Bian, Fei. 2018

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