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Whole genome sequencing of Luxi Black Head sheep for screening selection signatures associated with important traits

文献类型： 外文期刊

作者： Liu, Zhaohua 1 ; Tan, Xiuwen 1 ; Wang, Jianying 1 ; Jin, Qing 1 ; Meng, Xianfeng 1 ; Cai, Zhongfeng 3 ; Cui, Xukui 1 ; Wang, Ke 1 ;

作者机构： 1.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Key Lab Livestock & Poultry Multiom MARA, Jinan 250100, Peoples R China

2.Shandong Key Lab Anim Dis Control & Breeding, Jinan 250100, Peoples R China

3.Heze Anim Husb Workstat, Heze 274000, Peoples R China

关键词： Important Traits; Luxi Black Head Sheep; Selection Signatures; Whole Genome Sequencing

期刊名称：ANIMAL BIOSCIENCE

ISSN： 2765-0189

年卷期： 2022 年 35 卷 9 期

页码：

收录情况： SCI

摘要： Objective: Luxi Black Head sheep (LBH) is the first crossbreed specialized for meat production and was developed by crossbreeding Black Head Dorper sheep (DP) and Small Tailed Han sheep (STH) in the farming areas of northern China. Research on the genomic variations and selection signatures of LBH caused by continuous artificial selection is of great significance for identifying the genetic mechanisms of important traits of sheep and for the continuous breeding of LBH. Methods: We explored the genetic relationships of LBH, DP, and several Mongolian sheep breeds by constructing phylogenetic tree, principal component analysis and linkage disequilibrium analysis. In addition, we analysed 29 whole genomes of sheep. The genome- wide selection signatures have been scanned with four methods: heterozygosity (HP), fixation index (FST), cross -population extended haplotype homozygosity (XP-EHH) and the nucleo tide diversity (theta pi) ratio. Results: The genetic relationships analysis showed that LBH appeared to be an independent cluster closer to DP. The candidate signatures of positive selection in sheep genome revealed candidate genes for developmental process (HoxA gene cluster, BCL2L11, TSHR), immunity (CXCL6, CXCL1, SKAP2, PTK6, MST1R), growth (PDGFD, FGF18, SRF, SOCS2), and reproduction (BCAS3, TRIM24, ASTL, FNDC3A). Moreover, two signalling pathways closely related to reproduction, the thyroid hormone signalling pathway and the oxytocin signalling pathway, were detected. Conclusion: The selective sweep analysis of LBH genome revealed candidate genes and signalling pathways associated with developmental process, immunity, growth, and repro- duction. Our findings provide a valuable resource for sheep breeding and insight into the mechanisms of artificial selection.

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