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Microalgal Oil from Schizochytrium sp Prevents HFD-Induced Abdominal Fat Accumulation in Mice

文献类型： 外文期刊

作者： Yu, Jinhui 1 ; Ma, Yong 1 ; Sun, Jie 1 ; Ran, Liyuan 1 ; Li, Youwei 1 ; Wang, Ning 1 ; Yu, Tao 1 ; Gao, Wenting 1 ; Jia, Wen 1 ;

作者机构： 1.Dalian Med Univ, Inst Genome Engn Anim Models Human Dis, 9 West Sect,Lvshun S Rd, Dalian 116044, Liaoning, Peoples R China

2.Dalian Med Univ, Coll Integrat Med, Dalian, Liaoning, Peoples R China

3.Shandong Ctr Crop Germplasm Resources, Jinan, Shandong, Peoples R China

4.Shang Dong Acad Agr Sci, Biotechnol Res Ctr, Jinan, Shandong, Peoples R China

关键词： Anti-obesity;docosahexaenoic acid;eicosapentaenoic acid;microalgal oil;n-3 polyunsaturated fatty acids;Schizochytrium sp

期刊名称：JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION （ 影响因子：3.169； 五年影响因子：3.309 ）

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收录情况： SCI

摘要： Objective: Dietary n-3 polyunsaturated fatty acids (PUFAs), especially eicosapentaenoic acids (EPA) and docosahexaenoic acid (DHA), are proved to be effective in obesity reduction. Microalgal oil (MO) is an important alternative source of n-3 PUFAs that effectively alleviates obesity. The aim of the present study was to explore the anti-obesity effects of microalgal oil from Schizochytrium sp. (SMO) and to compare the effects of 2 SMOs (SMO1 and SMO2) with different levels of purity of n-3 PUFAs on high fat diet (HFD)-induced obesity in male C57BL/6J mice.Methods: Mice were randomly divided into 5 groups: (1) regular chow (RC); (2) HFD; (3) HFD + fish oil (FO); (4) HFD + SMO1; and (5) HFD + SMO2. Body weight and food intake were weekly monitored. After 16weeks of treatment, a glucose tolerance test (GTT) and an insulin tolerance test (ITT) were performed. Serum lipid profile, morphological changes in the liver and epididymal white adipose tissue (eWAT), and the mRNA expression of lipid metabolism-related genes were also examined.Results: SMO treatment significantly decreased HFD-induced abdominal fat accumulation, lowered the levels of triglycerides, cholesterol, and low-density lipoprotein, as did the positive control treated with FO. Morphological examination revealed a remarkable reduction in lipid droplet formation in the liver tissue and the particle size of eWAT. An alleviation of inflammation infiltration in eWAT caused by a high-fat diet was also observed. Real-time reverse transcription-polymerase chain reaction analysis examination confirmed that microalgal oil inhibited the gene expression of fatty acid synthase, sterol responsive element-binding protein-1c, and acetyl-CoA carboxylase but promoted that of hormone-sensitive lipase and lipoprotein lipase, carnitine palmitoyltransferase-1, and uncoupling proteins in the liver and eWAT. Moreover, similar anti-obesity effects were obtained with the same dosage but different purity of n-3 PUFAs.Conclusions: As an alternative n-3 PUFAs resource, dietary intake of SMO might be beneficial to prevent HFD-induced abdominal fat accumulation.

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