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Identification of Goose-Origin Parvovirus as a Cause of Newly Emerging Beak Atrophy and Dwarfism Syndrome in Ducklings

文献类型： 外文期刊

作者： Yu, Kexiang 1 ; Ma, Xiuli 1 ; Sheng, Zizhang 2 ; Qi, Lihong 1 ; Liu, Cunxia 1 ; Wang, Dan 3 ; Huang, Bing 1 ; Li, Feng 1 ; S 1 ;

作者机构： 1.Shandong Acad Agr Sci, Inst Poultry Sci, Jinan, Shandong, Peoples R China

2.Columbia Univ, Dept Biochem & Mol Biophys, New York, NY USA

3.South Dakota State Univ, Dept Biol & Microbiol, Brookings, SD 57007 USA

4.South Dakota State Univ, Dept Vet & Biomed Sci, Brookings, SD 57007 USA

期刊名称：JOURNAL OF CLINICAL MICROBIOLOGY （ 影响因子：5.948； 五年影响因子：5.345 ）

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收录情况： SCI

摘要： A recent epizootic outbreak, in China, of duck beak atrophy and dwarfism syndrome (BADS) was investigated using electron microscopic, genetic, and virological studies, which identified a parvovirus with a greater similarity to goose parvovirus (GPV) (97% protein homology) than to Muscovy duck parvovirus (MDPV) (90% protein homology). The new virus, provisionally designated GPV-QH15, was found to be antigenically more closely related to GPV than to MDPV in a virus neutralization assay. These findings were further supported by phylogenetic analysis showing that GPV-QH15 evolved from goose lineage parvoviruses, rather than from Muscovy duck-or other duck species-related parvoviruses. In all, two genetic lineages (GPV I and GPV II) were identified from the GPV samples analyzed, and GPV-QH15 was found to be closely clustered with two known gooseorigin parvoviruses (GPVa2006 and GPV1995), together forming a distinctive GPV IIa sublineage. Finally, structural modeling revealed that GPV-QH15 and the closely related viruses GPVa2006 and GPV1995 possessed identical clusters of receptor-interacting amino acid residues in the VP2 protein, a major determinant of viral receptor binding and host specificity. Significantly, these three viruses differed from MDPVs and other GPVs at these positions. Taken together, these results suggest that GPV-QH15 represents a new variant of goose-origin parvovirus that currently circulates in ducklings and causes BADS, a syndrome reported previously in Europe. This new finding highlights the need for future surveillance of GPV-QH15 in poultry in order to gain a better understanding of both the evolution and the biology of this emerging parvovirus.

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