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Two amino acid residues in ion channel protein M2 and polymerase protein PA contribute to replication difference of H5N1 influenza viruses in mice

文献类型： 外文期刊

作者： Xu, Chuantian 1 ; Chen, Hualan 2 ; Hu, Beixia 1 ; Yang, Shaohua 1 ; Zhang, Lin 1 ; Huang, Qinghua 1 ; Zhang, Xiumei 1 ;

作者机构： 1.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Shandong Key Lab Anim Dis Control & Breeding, Jinan 250100, Peoples R China

2.CAAS, Harbin Vet Res Inst, Minist Agr, Anim Influenza Lab, Harbin 150001, Peoples R China

3.CAAS, Harbin Vet Res Inst, Minist Agr, Natl Key Lab Vet Biotechnol, Harbin 150001, Peoples R China

关键词： M2;Mice;PA;Replication

期刊名称：VIRUS RESEARCH （ 影响因子：3.303； 五年影响因子：3.445 ）

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收录情况： SCI

摘要： A/swine/Fujian/1/2001 (FJ1) and A/Duck/Zhejiang/52/2000 (DK52) are H5N1 influenza viruses that are lethal in chickens. However, in mice, FJ1 is highly pathogenic, whereas DK52 cannot replicate at all. In this study, we used reverse genetics to demonstrate that amino acid residues at position 54 of polymerase acidic protein (PA) and position 26 of ion channel protein M2 of FJ1 and DK52 are important determinants for replication in mice. In addition, we prove that M2 and PA proteins contribute to the replication of H5N1 viruses in mice.

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