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Extraction and isolation of dictamnine, obacunone and fraxinellone from Dictamnus dasycarpus Turcz. by supercritical fluid extraction and high-speed counter-current chromatography

文献类型： 外文期刊

作者： Wang, Daijie 1 ; Lin, Yunliang 1 ; Lin, Xiaojing 1 ; Geng, Yanling 1 ; Wang, Xiao 1 ; Zhang, Jinjie 2 ; Qiu, Jiying 3 ;

作者机构： 1.Shandong Acad Sci, Proc Control Res Ctr TCM, Shandong Anal & Test Ctr, Jinan 250014, Peoples R China

2.Zhejiang Univ, Coll Biosyst Engn & Food Sci, Hangzhou 310030, Zhejiang, Peoples R China

3.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Jinan 250100, Shandong, Peoples R China

关键词： Dictamnine;Dictamnus dasycarpus;Obacunone

期刊名称：QUIMICA NOVA （ 影响因子：0.961； 五年影响因子：1.091 ）

ISSN：

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收录情况： SCI

摘要： Supercritical fluid extraction was used to extract active compounds from the Chinese traditional medicinal D. dasycarpus under the pressure of 30 MPa and temperature of 45 °C. Further separation and purification was established by high-speed counter-current chromatography (HSCCC) with a two-phase solvent system composed of n-hexane-ethyl acetate-methanol-water(1:0.8:1.3:0.9, volume ratio). The separation yielded a total of 47 mg of dictamnine, 24 mg of obacunone and 83 mg of fraxinellone from 1.0 g of the crude extract in one step separation with the purity of 99.2, 98.4 and 99.0%, respectively, as determined by HPLC. The chemical structures of these compounds were identified by ESI-MS, IR, 1H-NMR and 13C-NMR.

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