Lactate and Lactylation: Clinical Applications of Routine Carbon Source and Novel Modification in Human Diseases
文献类型： 外文期刊
作者： Wang, Zhimin 1 ; Hao, Dan 2 ; Zhao, Shuiying 1 ; Zhang, Ziyin 4 ; Zeng, Zhen 5 ; Wang, Xiao 6 ;
作者机构： 1.Zhengzhou Univ, Div Endocrinol & Metab Dis, Affiliated Hosp 1, Zhengzhou, Peoples R China
2.Univ Copenhagen, Dept Biol, Copenhagen, Denmark
3.Shijiazhuang Zhongnongtongchuang ZNTC Biotechnol C, Shijiazhuang, Peoples R China
4.Zhengzhou Univ, Div Informat, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China
5.Tsinghua Univ, Beijing Tsinghua Changgung Hosp, Sch Clin Med, Dept Obstet & Gynecol, Beijing, Peoples R China
6.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Jinan, Peoples R China
7.Konge Larsen ApS, Lyngby, Denmark
期刊名称：MOLECULAR & CELLULAR PROTEOMICS （ 影响因子：7.0； 五年影响因子：6.3 ）
ISSN：
年卷期： 2023 年 22 卷 10 期
页码：
收录情况： SCI
摘要： Cell metabolism generates numerous intermediate metabolites that could serve as feedback and feed -forward regulation substances for posttranslational modification. Lactate, a metabolic product of glycolysis, has recently been conceptualized to play a pleiotropic role in shaping cell identities through metabolic rewiring and epigenetic modifications. Lactate -derived carbons, sourced from glucose, mediate the crosstalk among glycolysis, lactate, and lactylation. Furthermore, the multiple metabolic fates of lactate make it an ideal substrate for metabolic imaging in clinical application. Several studies have identified the crucial role of protein lactylation in human diseases associated with cell fate determination, embryonic development, inflammation, neoplasm, and neuropsychiatric disorders. Herein, this review will focus on the metabolic fate of lactate -derived carbon to provide useful information for further research and therapeutic approaches in human diseases. We comprehensively discuss its role in reprogramming and modification during the regulation of glycolysis, the clinical translation prospects of the hyperpolarized lactate signal, lactyl modification in human diseases, and its application with other techniques and omics.
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