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Selection characterization on overlapping reading frame of multiple-protein-encoding P gene in Newcastle disease virus

文献类型： 外文期刊

作者： Liang, Jun-Wen 1 ; Tian, Fu-Lin 2 ; Lan, Zhou-Ran 2 ; Huang, Bing 3 ; Zhuang, Wen-Zhong 1 ;

作者机构： 1.Shandong Normal Univ, Coll Life Sci, Jinan 250014, Shandong, Peoples R China

2.Shandong Prov Ctr Anim Dis Control & Prevent, Jinan 250022, Peoples R China

3.Shandong Acad Agr Sci, Inst Poultry Sci, Jinan 250023, Peoples R China

关键词： nucleotides GenBank sequence data;gene distribution;gene evolutionary relationship

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）

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收录情况： SCI

摘要： The aim of this study was to characterize the molecular evolution of P and V protein genes of the Newcastle disease virus (NDV). The P gene sequences of 55 NDV isolates, representing different chronological and geographic origins, were obtained from GenBank. In this paper, the evolution of the specific regions of the NDV P gene, encoding the P and V proteins, was analyzed. The nucleotides from the shared P/V region encoded the co-amino terminus of the two proteins, while the P-V/V-P region was respectively encoded by the nucleotides within the P ORF or the V ORF in the common sequence (after the mRNA editing site). As well, the P-cut region exclusively encoded the P protein. Finally, the P-V and V-P regions were further broken down into P1 and P2 fragments with the corresponding V1 and V2 fragments. In the P gene, the P-cut portion corresponding to the C-terminal of the P protein was the most highly conserved, while the P-V region was the most variable. This was interpreted as a lower constraint for function in the common sequence than in the unique P sequence that is known to contain an important function. Interestingly, in the common P-V/V-P function, variability of V1 was compensated by a higher conservation of the corresponding P1, and conversely for the P2/V2, which suggested that the flexibility of one ORF with less function served the purpose of allowing positive selection in the other overlapping ORF that exhibited more function. (C0) 2010 Elsevier B.V. All rights reserved.

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