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PREPARATIVE SEPARATION AND PURIFICATION OF SESQUITERPENOIDS FROM Tussilago farfara L. BY HIGH-SPEED COUNTER-CURRENT CHROMATOGRAPHY

文献类型： 外文期刊

作者： Wang, Daijie 1 ; Fang, Lei 1 ; Wang, Xiao 1 ; Qiu, Jiying 2 ; Huang, Luqi 3 ;

作者机构： 1.Shandong Acad Sci, Shandong Anal & Test Ctr, Jinan 250014, Shandong, Peoples R China

2.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Jinan 250100, Shandong, Peoples R China

3.Acad Tradit Chinese Med, Inst Chinese Mat Med, Beijing 100700, Peoples R China

关键词： high-speed counter-current chromatography;sesquiterpenoids;Thissilago farfara L

期刊名称：QUIMICA NOVA （ 影响因子：0.961； 五年影响因子：1.091 ）

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收录情况： SCI

摘要： Preparative high-speed counter-current chromatography (HSCCC) was successfully applied for separation and purification of sesquiterpenoids from an extract of Tussilago farfara L. with a two-phase solvent system composed of n-hexane-ethyl acetate-methanol-water (1:0.5:1.1:0.3, v/v/v/v). The separation produced a total of 32 mg of tussilagone. 18 mg of 14-acetoxy-7β-(3'- ethyl cia-crotonoyloxy)-lα-(2-methyl butyryloxy)-notonipetranone and 21 mg of 7β-(3'-ethyl cis-crotonoyloxy)-lα-(2- methyl butyryloxy)-3,14-dehydro-Z-notonipetranone from 500 mg of the crude extract in one step separation with the purity of 99.5, 99.4 and 99. 1%, respectively, as determined by HPLC. The structures of these compounds were identified by ESI-MS, ~1H-NMR and ~(13)C-NMR.

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