Two new monoterpene lactones from Ligularia rumicifolia (JRDrumm.) SWLiu and their anti-proliferative activities
文献类型： 外文期刊
作者： Zhang, Jing 1 ; Jiang, Wei 1 ; Cao, Hong-Jie 2 ; Qu, Yanbo 1 ; Liao, Zhi-Xin 1 ; Liu, Chao 3 ; Sun, Jin-Yue;
作者机构： 1.Southeast Univ, Jiangsu Prov Hitech Key Lab Biomed Res, Sch Chem & Chem Engn, Dept Pharmaceut Engn, Nanjing 211189, Jiangsu, Peoples R China
2.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Key Lab Agroprod Proc Technol Shandong Prov, Key Lab Novel Food Resources Proc,Minist Agr, Jinan 250100, Shandong, Peoples R China
3.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Key Lab Agroprod Proc Technol Shando
关键词： Ligularia rumicifolia (JRDrumm.) SWLiu; Monoterpene lactones; Anti-proliferative
期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.679； 五年影响因子：1.861 ）
ISSN： 1874-3900
年卷期： 2018 年 28 卷
页码：
收录情况： SCI
摘要： A phytochemical study of the EtOAc extract of Ligularia rumicifolia (J.R.Drumm.) S.W.Liu led to the isolation of two new monoterpene lactones (1-2) named (2S,3S,5R)-5-ethyl-2,3-dimethyl-6-oxoterahydro-2H-pyran-2-carboxylic acid and (2S,3S,5R)-5-ethyl-2,3-dimethyl-6-oxoterahydro-2H-pyran-2-carboxylic acid methyl ester, along with nine known compounds (3-11). All compounds were isolated from this species for the first time. Their structures were established on the basis of spectroscopic methods. The cytotoxic activity of Compound 2 was weak, with the lowest IC50 value of 80.84 mu M against MCF-7 cells. Compound 1 exhibited better anti-proliferative activities against MCF-7, T-24, HepG-2 and SKOV-3 cell lines than Compound 2, with the lowest IC50 value of 66.12 mu M against MCF-7 cells.
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