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Isolation and Identification of a Novel Rabies Virus Lineage in China with Natural Recombinant Nucleoprotein Gene

文献类型： 外文期刊

作者： He, Cheng-Qiang 1 ; Meng, Sheng-Li 2 ; Yan, Hong-Yan 1 ; Ding, Nai-Zheng 1 ; He, Hong-Bin 3 ; Yan, Jia-Xin 2 ; Xu, Ge-Lin 2 ;

作者机构： 1.Shandong Normal Univ, Coll Life Sci, Key Lab Syst Biol Univ Shandong, Jinan, Peoples R China

2.Wuhan Inst Biol Prod, Wuhan, Peoples R China

3.Shandong Acad Agr Sci, Dairy Cattle Res Ctr, Jinan, Peoples R China

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2012 年 7 卷 12 期

页码：

收录情况： SCI

摘要： Rabies virus (RABV) causes severe neurological disease and death. As an important mechanism for generating genetic diversity in viruses, homologous recombination can lead to the emergence of novel virus strains with increased virulence and changed host tropism. However, it is still unclear whether recombination plays a role in the evolution of RABV. In this study, we isolated and sequenced four circulating RABV strains in China. Phylogenetic analyses identified a novel lineage of hybrid origin that comprises two different strains, J and CQ92. Analyses revealed that the virus 39 untranslated region (UTR) and part of the N gene (approximate 500 nt in length) were likely derived from Chinese lineage I while the other part of the genomic sequence was homologous to Chinese lineage II. Our findings reveal that homologous recombination can occur naturally in the field and shape the genetic structure of RABV populations. Citation: He C-Q, Meng S-L, Yan H-Y, Ding N-Z, He H-B, et al. (2012) Isolation and Identification of a Novel Rabies Virus Lineage in China with Natural Recombinant Nucleoprotein Gene. PLoS ONE 7(12): e49992. doi: 10.1371/journal.pone.0049992

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