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Intragenic Recombination as a Mechanism of Genetic Diversity in Bluetongue Virus

文献类型： 外文期刊

作者： He, Cheng-Qiang 1 ; Ding, Nai-Zheng 1 ; He, Mei 1 ; Li, Shan-Ni 1 ; Wang, Xing-Ming 1 ; He, Hong-Bin 3 ; Liu, Xin-Fa 1 ;

作者机构： 1.Cent S Univ, Sch Biol Sci & Technol, Changsha 410012, Hunan, Peoples R China

2.Shandong Normal Univ, Coll Life Sci, Jinan 250014, Peoples R China

3.Shandong Acad Agr Sci, Inst Dairy Cattle Res, Jinan 250100, Peoples R China

关键词： gene: expression;mutation genetic diversity;genbank sequence data

期刊名称：JOURNAL OF VIROLOGY （ 影响因子：5.103； 五年影响因子：5.078 ）

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收录情况： SCI

摘要： Bluetongue (BT), caused by Bluetongue virus (BTV), is an economically important disease affecting sheep, deer, cattle, and goats. Since 1998, a series of BT outbreaks have spread across much of southern and central Europe. To study why the epidemiology of the virus happens to change, it is important to fully know the mechanisms resulting in its genetic diversity. Gene mutation and segment reassortment have been considered as the key forces driving the evolution of BTV. However, it is still unknown whether intragenic recombination can occur and contribute to the process in the virus. We present here several BTV groups containing mosaic genes to reveal that intragenic recombination can take place between the virus strains and play a potential role in bringing novel BTV lineages.

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