A geniposide-phospholipid complex ameliorates posthyperuricemia chronic kidney disease induced by inflammatory reactions and oxidative stress
文献类型： 外文期刊
作者： Wang, Mu-xuan 1 ; Wang, Min-min 4 ; Liu, Chao 3 ; Chen, Jia-shu 3 ; Liu, Jian-shu 1 ; Guo, Xu 3 ; Zhang, Meng-qi 3 ; Zhang, Jing 3 ; Sun, Jin-yue 3 ; Liao, Zhi-xin 1 ;
作者机构： 1.Southeast Univ, Sch Chem & Chem Engn, Dept Pharmaceut Engn, Nanjing 211189, Peoples R China
2.Southeast Univ, Jiangsu Prov Hitech Key Lab Biomed Res, Nanjing 211189, Peoples R China
3.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Key Lab Novel Food Resources Proc, Key Lab Agroprod Proc Technol Shandong Prov,Minist, Jinan 250100, Peoples R China
4.Taian Tradit Chinese Med Hosp, Tai An 271000, Peoples R China
5.Shanxi Funct Food Engn Ctr Co Ltd, Xian 710000, Peoples R China
关键词： Hyperuricemia; Chronic kidney disease; Geniposide-phospholipid complex; Inflammatory reaction; Oxidative stress
期刊名称：EUROPEAN JOURNAL OF PHARMACOLOGY （ 影响因子：5.195； 五年影响因子：4.721 ）
ISSN： 0014-2999
年卷期： 2022 年 930 卷
页码：
收录情况： SCI
摘要： Hyperuricemia is a common metabolic disease and is one of the factors that could induce chronic kidney disease (CKD). Geniposide (GEN) is a typical natural iridoid glucoside compound with a series of biological activities, but the poor bioavailability of GEN limits its clinical application. In this context, the pharmacological activity of the geniposide-phospholipid complex (GEN-PLC) in ameliorating posthyperuricemia CKD was evaluated by in vitro and in vivo experiments in this study. In vitro cell experiments showed that GEN-PLC treatment markedly decreased inflammatory cytokine levels and reactive oxygen species levels compared with those of GEN in uric acid-treated HKC cells. In vivo research results confirmed that a high concentration of uric acid could cause CKD by increasing inflammatory cytokines and reactive oxygen species in hyperuricemic mice. At the same time, GEN-PLC could regulate the PI3K/AKT/NF-kappa B and Keap1/Nrf2/HO-1 signaling pathways to effectively inhibit the inflammatory response and oxidative stress, thereby ameliorating posthyperuricemia CKD, and the thera-peutic effect was better than that of GEN. In addition, the preparation technology of GEN-PLC was optimized, and the physiochemical analysis explained the intermolecular interactions of the two components. Based on the research results, GEN-PLC could enhance the bioavailability of GEN and become a promising candidate for clinical drug development.
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