文献类型： 外文期刊

作者： Zeng, Lin ¹ ; Liu, He-Qun ¹ ; Tu, Xiao-Long ¹¹ ; Ji, Chang-Mian ² ; Gou, Xiao ³ ; Esmailizadeh, Ali ⁴ ; Wang, Sheng ¹ ; Wa ¹ ;

作者机构： 1.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Biosafety Monitoring & Mol Breedin, Haikou 571101, Hainan, Peoples R China

3.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Yunnan, Peoples R China

4.Shahid Bahonar Univ Kerman, Fac Agr, Dept Anim Sci, PB 76169-133, Kerman, Iran

5.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650204, Yunnan, Peoples R China

6.Chinese Acad Sci, Sino Africa Joint Res Ctr, Kunming 650223, Yunnan, Peoples R China

7.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China

8.Chinese Acad Sci, Inst Three River Source Natl Pk, Xining 810008, Qinghai, Peoples R China

9.Queen Mary Univ London, Sch Biol & Chem Sci, London E1 4NS, England

10.Albert Einstein Coll Med, Dept Genet, New York, NY 10461 USA

11.Annord Gene Tech Beijing Co Ltd, Beijing 100176, Peoples R China

12.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Yunnan Lab Mol Biol Domest Anim,Germplasm Bank Wi, Kunming 650223, Yunnan, Peoples R China

13.Univ Ibadan, Dept Vet Med, Ibadan 200284, Nigeria

14.Fed Coll Anim Hlth & Prod Technol, Ibadan 234102, Nigeria

15.Taraba State Minist Agr & Nat Resources, Jalingo 660221, Nigeria

16.Div Vet Off, Serti 663101, Nigeria

17.Jomo Kenyatta Univ Agr & Technol, Inst Biotechnol Res, Nairobi 6200000200, Kenya

18.Natl Museums Kenya, Dept Zool, Nairobi 4065800100, Kenya

19.Minist Agr Fisheries & Irrigat, State Dept Livestock, Nairobi 00625, Kenya

20.Shandong Acad Agr Sci, Dairy Cattle Res Ctr, Equus Lab, Jinan 250131, Shandong, Peoples R China

21.Liaocheng Univ, Liaocheng Res Inst Donkey High Efficiency Breedin, Liaocheng 252059, Shandong, Peoples R China

22.Chinese Acad Agr Sci CAAS, Inst Anim Sci, CAAS ILRI Joint Lab Livestock & Forage Genet Reso, Beijing 100193, Peoples R China

23.Biomarker Technol Corp, Beijing 101300, Peoples R China

24.Ludwig Maximilians Univ Munchen, Dept Vet Sci, Palaeogen Grp, D-80539 Munich, Germany

关键词： Kiang; Donkey; High altitude; Adaptation; Selection

期刊名称：ZOOLOGICAL RESEARCH （ 影响因子：4.56； ）

ISSN： 2095-8137

年卷期： 2021 年 42 卷 4 期

页码：

收录情况： SCI

摘要： Over the last several hundred years, donkeys have adapted to high-altitude conditions on the Tibetan Plateau. Interestingly, the kiang, a closely related equid species, also inhabits this region. Previous reports have demonstrated the importance of specific genes and adaptive introgression in divergent lineages for adaptation to hypoxic conditions on the Tibetan Plateau. Here, we assessed whether donkeys and kiangs adapted to the Tibetan Plateau via the same or different biological pathways and whether adaptive introgression has occurred. We assembled a de novo genome from a kiang individual and analyzed the genomes of five kiangs and 93 donkeys (including 24 from the Tibetan Plateau). Our analyses suggested the existence of a strong hard selective sweep at the EPAS1 locus in kiangs. In Tibetan donkeys, however, another gene, i.e., EGLN1, was likely involved in their adaptation to high altitude. In addition, admixture analysis found no evidence for interspecific gene flow between kiangs and Tibetan donkeys. Our findings indicate that despite the short evolutionary time scale since the arrival of donkeys on the Tibetan Plateau, as well as the existence of a closely related species already adapted to hypoxia, Tibetan donkeys did not acquire adaptation via admixture but instead evolved adaptations via a different biological pathway.