A heterophil/lymphocyte-selected population reveals the phosphatase PTPRJ is associated with immune defense in chickens
文献类型： 外文期刊
作者： Wang, Jie 1 ; Zhang, Jin 1 ; Wang, Qiao 1 ; Zhang, Qi 1 ; Thiam, Mamadou 1 ; Zhu, Bo 1 ; Ying, Fan 1 ; Elsharkawy, Mohamed Shafey 1 ; Zheng, Maiqing 1 ; Wen, Jie 1 ; Li, Qinghe 1 ; Zhao, Guiping 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing 100193, Peoples R China
2.Shandong Acad Agr Sci, Poultry Inst, Jinan 250100, Peoples R China
期刊名称：COMMUNICATIONS BIOLOGY （ 影响因子：5.9； 五年影响因子：6.3 ）
ISSN：
年卷期： 2023 年 6 卷 1 期
页码：
收录情况： SCI
摘要： Quantification of leukocyte profiles is among the simplest measures of animal immune function. However, the relationship between H/L ratio and innate immunity and the measure's utility as an index for heterophil function remains to be analyzed. Variants associated with H/L ratio were fine-mapped based on the resequencing of 249 chickens of different generations and an F2 segregating population generated by crossing selection and control lines. H/L ratio in the selection line was associated with a selective sweep of mutations in protein tyrosine phosphatase, receptor type J (PTPRJ), which affects proliferation and differentiation of heterophils through its downstream regulatory genes. The SNP downstream of PTPRJ (rs736799474) have a universal effect on H/L, with CC homozygotes exhibiting improved heterophil function because of downregulated PTPRJ expression. In short, we systematically elucidated the genetic basis of the change in heterophil function resulting from H/L selection by identifying the regulatory gene (PTPRJ) and causative SNP. Genomic and transcriptomic profiling in Jingxing yellow chickens selected for a heterophil-lymphocyte ratio (H/L) provides further insight on the genetic basis of H/L and identifies PTPRJ as a relevant factor.
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