Target animal safety testing of an oral salicylanilide suspension, oxyclozanide, for the treatment of fascioliasis in bovine in China
文献类型： 外文期刊
作者： Dong, Zhen 1 ; Sun, Jichao 1 ; Bai, Yubin 1 ; Wang, Weiwei 1 ; Zhu, Yueming 4 ; Li, Bing 1 ; Cheng, Fusheng 1 ; Wei, Xiao 1 ;
作者机构： 1.Chinese Acad Agr Sci, Lanzhou Inst Husb & Pharmaceut Sci, Beijing, Peoples R China
2.Minist Agr, Key Lab Vet Pharmaceut Dev, Lanzhou, Gansu, Peoples R China
3.Key Lab New Anim Drug Project Gansu Prov, Lanzhou, Gansu, Peoples R China
4.Zhang Ye Wan He Gross Planting & Anim Husb Sci &, Zhangye, Peoples R China
5.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Jinan, Shandong, Peoples R China
关键词： Toxicity risk; Oxyclozanide suspension; Safety; Target animal; Bovine
期刊名称：REGULATORY TOXICOLOGY AND PHARMACOLOGY （ 影响因子：3.271； 五年影响因子：4.291 ）
ISSN： 0273-2300
年卷期： 2019 年 103 卷
页码：
收录情况： SCI
摘要： The aim of this study was to determine the potential toxicity risk of an oxyclozanide suspension to the target animal, bovine. In this experiment, 32 Simmental beef cattle were fattened and fed a full-price diet without antimicrobial agents. The test cattle were divided into 4 groups, which were treated with 0, 1, 3, and 5 times the recommended dosage through continuous intermittent oral administration at intervals of 2 days. The body weight of the cattle was recorded before and after the experiment, and the weight changes were calculated. The safety of the drugs was evaluated by weight gain, observation of clinical toxicity, haematology, clinical chemistry and histopathology. The results showed that the cattle had different degrees of diarrhoea, loss of appetite and depression after administration. The results of clinicopathology had no significant effect. The results of pathological examination showed that there was a certain degree of damage in the 5 times recommended dose group. The recommended dose was safe to use. Thus, the recommended dose should be given by a single oral administration to ensure the safe use of this drug in the clinic.
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