Are two beneficial mutations (p.Q249R and 90-bp Indel) within the ovine BMPRIB gene associated with growth traits?
文献类型： 外文期刊
作者： Xu, Hongwei 1 ; Akhmet, Nazar 2 ; Luo, Yunyun 2 ; Guo, Zhenggang 3 ; Pan, Chuanying 2 ; Song, Enliang 4 ; Malmakov, Nurlan 5 ; Akhatayeva, Zhanerke 2 ; Lan, Xianyong 2 ;
作者机构： 1.Northwest Minzu Univ, Coll Life Sci & Engn, Lanzhou, Gansu, Peoples R China
2.Northwest A&F Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod Shaanxi Prov, Yangling, Shaanxi, Peoples R China
3.Bijie Anim Husb & Vet Sci Res Inst, Bijie, Guizhou, Peoples R China
4.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Shandong Key Lab Anim Dis Control & Breeding, Jinan, Peoples R China
5.Kazakh Sci Res Inst Anim Husb & Fodder Prod, Sci Res Inst Sheep Breeding Branch, Mynbaev, Almaty Region, Kazakhstan
关键词： sheep; FecB (BMPRIB); polymorphism; growth traits; MAS
期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：3.2； 五年影响因子：3.5 ）
ISSN：
年卷期： 2024 年 10 卷
页码：
收录情况： SCI
摘要： Background: The problem of achieving economic efficiency in sheep breeding can be largely solved by increasing sheep productivity. Recently, the BMPRIB gene has been revealed by GWAS as a potential candidate gene for sheep body morphometric traits. Therefore, the present study aimed to investigate whether genetic polymorphisms (p.Q249R SNP and 90-bp deletion) in the BMPRIB gene are associated with sheep growth traits. Methods: PCR-based genotyping was performed on 1,875 sheep, including 1,191 Guiqian semi-fine wool (GQSFW), 560 Luxi Blackhead (LXBH), 55 Lanzhou fat-tailed (LZFT), and 69 Weining (WN) sheep. Genotype-phenotype association was assessed using the independent samples t-test and ANOVA. The significance level was set at alpha(original) < 0.05. The threshold p-value for significance was adjusted after correction for multiple comparisons using the Bonferroni correction. Results: After the Bonferroni correction, it was found that individuals with FecB(+)/FecB(+) genotypes of the p.Q249R had significantly better growth traits in LXBH ewe lambs, including the body length, chest width, paunch girth, cannon circumference, and hip width (P<0.0005). Meanwhile, associations were observed between 90-bp deletion polymorphism and several growth traits (body length, body height, chest depth, and canon circumference) in GQSFW ewe adults after the Bonferroni correction (P < 0.0002), and individuals with the "DD" genotypes had greater growth traits. Conclusion: Our findings align with the experimental observations from GWAS, which identified the BMPRIB gene as a potential candidate gene for body measurement traits. These findings not only confirm the previous study's results but also expand on them. Therefore, further investigations regarding the impact of BMPRIB polymorphisms on growth traits are necessary in other sheep breeds.
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