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Pathogenicity and complete genome sequence of a fowl adenovirus serotype 8b isolate from China

文献类型： 外文期刊

作者： Huang, Qinghua 1 ; Ma, Xinxin 1 ; Huang, Xiaoying 1 ; Huang, Yanyan 1 ; Yang, Shaohua 1 ; Zhang, Lin 1 ; Cui, Ning 1 ; Xu 1 ;

作者机构： 1.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Shandong Key Lab Anim Dis Control & Breeding, Jinan 250100, Shandong, Peoples R China

2.Shandong Agr Univ, Coll Vet Med, Dept Vet Prevent Med, 61 Daizong St, Tai An 271018, Shandong, Peoples R China

关键词： fowl adenovirus serotype 8b; genome; evolution; phylogenetic analysis; pathogenicity

期刊名称：POULTRY SCIENCE （ 影响因子：3.352； 五年影响因子：3.679 ）

ISSN： 0032-5791

年卷期： 2019 年 98 卷 2 期

页码：

收录情况： SCI

摘要： In this study, we determined and analyzed the complete nucleotide sequence of the genome of a fowl adenovirus isolate SD1356 in China and examined its pathogenicity in specific pathogen-free chick embryos and newly hatched chicks. The full genome of SD1356 was 44,454 nucleotides in length with 58.1% G + C content. Sequence alignment and phylogenetic analysis revealed that strain SD1356 was clustered together belonging to serotype 8b of fowl adenoviruses E species (FAdV-8b). No regions homologous to early regions E1, E3, and E4 of mastadenoviruses were recognized, and being very similar to the typical organization of FAdV-E genomes. All infected embryos died 4-6 d post-inoculation with visible lesions, such as hyperemic, stunting, and clubbed down, etc. Additionally, adenovirus was found in tissues or cloacal swabs of all infected birds and most of the contact uninfected controls, despite lack of clinical signs and pathological changes. Together, our study describes the genomic characteristics of an FAdV-8b strain isolated in China. The reported FAdV-8b strain SD1356 is fetal to chick embryos and possesses horizontal transmission capacity in chickens.

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