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An epidemiological investigation of porcine circovirus 3 infection in cattle in Shandong province, China

文献类型： 外文期刊

作者： Wang, Wei 1 ; Sun, Wenchao 1 ; Cao, Liang 3 ; Zheng, Min 4 ; Zhu, Yilong 3 ; Li, Wenjie 1 ; Liu, Cunxia 5 ; Zhuang, Xinyu 3 ;

作者机构： 1.Guangxi Univ, Coll Anim Sci & Technol, Nanning 530004, Peoples R China

2.Wenzhou Univ, Inst Virol, Wenzhou 325035, Peoples R China

3.Acad Mil Med Sci, Inst Mil Vet Med, Changchun 130122, Jilin, Peoples R China

4.Acad Mil Med Sci, Inst Mil Vet, Guangxi Ctr Anim Dis Control & Prevent, Nanning, Peoples R China

5.Shandong Acad Agr Sci, Inst Poultry Sci, Jinan, Shandong, Peoples R China

关键词： Porcine circovirus type 3; Bovine; Epidemiology; Phylogenetic analysis

期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.741； 五年影响因子：2.955 ）

ISSN： 1746-6148

年卷期： 2019 年 15 卷

页码：

收录情况： SCI

摘要： Background: Porcine circovirus type 3 (PCV3) is a single-stranded, closed circular DNA virus, which causes porcine dermatitis and nephropathy syndrome (PDNS), multisystemic inflammation, and reproductive failure. The present study aimed to investigate the seroprevalence of PCV3 in cattle (Bos taurus) in Shandong province, China, and examine its genome diversity. Results: PCR amplification and sequencing showed that 74 of 213 bovine samples (34.7%) were positive for PCV3. Among them, the capsid gene (n=12) and the complete genome (n = 4) were sequenced. These sequences had high identities to the reference capsid gene (98.0-100%) and the complete genome (97.5-99.8%). The PCV3 strains were classified into two different genotypes (PCV3a and PCV3b), according to phylogenetic analysis based on the complete genome and capsid gene sequences. Specifically, the bovine-origin strains in this study were grouped into PCV3a, showing a close relationship with PCV3-US/SD2016 (American strain; GenBank: KX966193.1). Notably, a comparison of the inferred amino acid sequences revealed a mutation from D124 to Y124. Conclusion: This was the first seroprevalence and genetic investigation of PCV3 in cattle in Shandong province, China. The results could provide insights into the epidemiology and pathogenesis of this important virus.

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