文献类型： 外文期刊
作者： Jiang, Dandan 1 ; Jiang, Chenlong 1 ; Sui, Chao 2 ; Wu, Xiangju 2 ; Hu, Yue 2 ; Lee, Changhee 3 ; Cong, Xiaoyan 2 ; Li, Juntong 2 ; Du, Yijun 2 ; Qi, Jing 2 ;
作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Key Lab Anim Dis Diagnost & Immunol, Minist Agr,MOE Int Joint Collaborat Res Lab Anim H, Nanjing 210095, Peoples R China
2.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Shandong Key Lab Anim Dis Control & Breeding, Jinan, Shandong, Peoples R China
3.Gyeongsang Natl Univ, Coll Vet Med, Jinju 52828, South Korea
4.Gyeongsang Natl Univ, Virus Vaccine Res Ctr, Jinju 52828, South Korea
关键词： Pseudorabies virus; IFN-?; ISGs; SNONO
期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.246； 五年影响因子：3.565 ）
ISSN： 0378-1135
年卷期： 2022 年 275 卷
页码：
收录情况： SCI
摘要： Pseudorabies virus (PRV) is a member of the genus Varicellovirus, family Herpesviridae and causes Aujeszky's disease to lead to huge economic losses in the global pig industry. The Non-POU domain-containing octamer-binding protein (NONO), as a Drosophila behavior/human splicing (DBHS) protein, plays a key role in multi-ple biological functions in cells, including transcriptional regulation, RNA splicing, DNA repair and so on. However, whether swine NONO (sNONO) inhibits PRV infection is less understood. In this study, we showed that sNONO was a crucial host factor for antagonizing PRV infection and positive regulated transcription levels of ISGs. After PRV infection, sNONO enhanced the activation of IFN-beta promoter and IFN-beta expression. Furthermore, knockout of sNONO in PAM-KNU cells impaired activation of type I IFN pathway and increased PRV propagation. Taken together, we have first elucidated the anti-PRV function and mechanism of sNONO, which may provide a new strategy for preventing DNA virus infection.
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