Two new diterpenoids with their antiproliferative activities from the supercritical fluid extraction of Croton crassifolius root
文献类型： 外文期刊
作者： Liu, Chao 1 ; Zhang, Rui-rui 1 ; Niu, Qing-lin 2 ; Zhang, Jing 1 ; Wang, Mu-xuan 1 ; Meng, Na-na 1 ; Wang, Qing 1 ; Sun, 1 ;
作者机构： 1.Shandong Acad Agr Sci, Key Lab Novel Food Resources Proc, Key Lab Agroprod Proc Technol Shandong Prov, Minist Agr & Rural Affairs,Inst Agrofood Sci & Te, Jinan, Peoples R China
2.Shandong Inst Pomol, Shandong Prov Key Lab Fruit Tree Biotechnol Breed, Tai An, Shandong, Peoples R China
关键词： Croton crassifolius; diterpenoid; antiproliferative
期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）
ISSN： 1478-6419
年卷期：
页码：
收录情况： SCI
摘要： Supercritical fluid extraction was applied to obtain the lower polarity extracts from Croton crassifolius roots, and chemical investigation of which led to the isolation and identification of two new diterpenoids, named crassifolius P (1) and crassifolius Q (2). In vitro anti-proliferative activities of compounds 1 and 2 on A549, Hep-G2 and Hela tumor cell lines were evaluated. The two new compounds exhibited obvious selectivity to tumor cells with IC50 values ranging from 20.43 +/- 1.18 mu M to 25.72 +/- 1.32 mu M.
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