文献类型： 外文期刊
作者： Chen, Jieteng 1 ; Mu, Xiaohuan 2 ; Liu, Huiling 2 ; Yong, Qiyao 2 ; Ouyang, Xiaoman 2 ; Liu, Yan 1 ; Zheng, Li 1 ; Chen, Hao 1 ; Zhai, Yifan 1 ; Ma, Jie 3 ; Meng, Liang 3 ; Liu, Shanshan 3 ; Zheng, Hao 1 ;
作者机构： 1.Shandong Acad Agr Sci, Inst Plant Protect, Jinan 250100, Peoples R China
2.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
3.BGI Qingdao, Qingdao 266555, Peoples R China
关键词： Bumblebee; Rotenone; Single -nuclei sequencing; Glial cell; Dopaminergic neuron
期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：9.8； 五年影响因子：9.6 ）
ISSN： 0048-9697
年卷期： 2024 年 907 卷
页码：
收录情况： SCI
摘要： Bumblebees are essential pollinators of both wildflowers and crops and face multiple anthropogenic stressors, particularly the utilization of pesticides. Rotenone is an extensively applied neurotoxic pesticide that possesses insecticidal activities against a wide range of pests. However, whether environmentally realistic exposure levels of rotenone can damage neurons in bumblebee brains is still uncertain. Using single-cell RNA-seq, we revealed that rotenone induced cell-specific responses in bumblebee brains, emphasizing the disruption of energy meta-bolism and mitochondrial dysfunction in glial cells. Correspondingly, the gene regulatory network associated with neurotransmission was also suppressed. Notably, rotenone could specially reduce the number of dopaminergic neurons, impairing bumblebee's ability to fly and crawl. We also found impaired intestinal motility in rotenone-treated bumblebees. Finally, we demonstrated that many differentially expressed genes in our snRNA-seq data overlapped with rotenone-induced Parkinson's disease risk genes, especially in glial cells. Although rotenone is widely used owing to its hypotoxicity, we found that environmentally realistic exposure levels of rotenone induced disturbed glial energetics and locomotor dysfunction in bumblebees, which may lead to an indirect decline in this essential pollinator.
- 相关文献
作者其他论文 更多>>
-
Predictions of Milk Fatty Acid Contents by Mid-Infrared Spectroscopy in Chinese Holstein Cows
作者：Zhao, Xiuxin;Song, Yuetong;Zhang, Fan;Wang, Kun;Zhang, Miao;Gao, Yundong;Wang, Xiao;Li, Jianbin;Zhao, Xiuxin;Zhang, Yuanpei;Cai, Gaozhan;Xue, Guanghui;Liu, Yan;Song, Yuetong;Sun, Dongxiao;Song, Yuetong;Chen, Kewei;Wang, Kun;Zhang, Miao
关键词：prediction; milk; fatty acid content; mid-infrared spectroscopy; Chinese Holstein cow
-
Enzymatic fermentation of rapeseed cake significantly improved the soil environment of tea rhizosphere
作者：Song, Yujie;Wang, Huan;Zhang, Shuning;Fan, Kai;Mao, Yilin;Zhang, Jie;Han, Xiao;Chen, Hao;Xu, Yang;Sun, Kangwei;Wang, Yu;Sun, Litao;Ding, Zhaotang
关键词：Camellia sinensis; Rapeseed cake; Rhizosphere microorganisms; Soil metabolites
-
The single-cell transcriptome and chromatin accessibility datasets of peripheral blood mononuclear cells in Chinese holstein cattle
作者：Wang, Xiao;Zhang, Fan;Wang, Kun;Zhang, Miao;Li, Rongling;Gao, Yundong;Li, Jianbin;Gao, Yahui;Li, Cong-jun;Liu, George E.;Fang, Lingzhao;Zhao, Xiuxin;Zhang, Yuanpei;Cai, Gaozhan;Xue, Guanghui;Liu, Yan;Wang, Lingling
关键词：Chinese Holstein cattle; Peripheral blood mononuclear cell; Lipopolysaccharide; Single-cell accessibility dataset; Transcriptome; Chromatin
-
Analysis of leaf forage value and screening of different populations of Pteroceltis tatarinowii, a rare and endemic species in China
作者：Gao, Yun;Cheng, Tian-Tian;Liu, Qing-Zhong;Qiao, Qian;Cheng, Tian-Tian;Zhang, Chun-Xiang;Yan, Yu;Zhang, Lin;Liu, Yan;Qiao, Qian
关键词：Pteroceltis tatarinowii; woody forage; crude protein (CP); forage value; population diversity
-
Tweedle gene family of Drosophila suzukii (Matsumura) larva enhances the basal tolerance to cold and hypoxia
作者：Li, Zhihong;Wang, Xiaoxue;Liu, Lijun;Guo, Shaokun;Yan, Shuo;Shen, Jie;Ullah, Farman;Li, Zhihong;Wang, Xiaoxue;Liu, Lijun;Guo, Shaokun;Yan, Shuo;Shen, Jie;Ullah, Farman;Li, Zhihong;Liu, Bo;Zhai, Yifan
关键词：basal tolerance; cold-hypoxia; Drosophilidae transcriptome; Tweedle (Twdl) gene
-
Deciphering the cellular heterogeneity of the insect brain with single-cell RNA sequencing
作者：Wang, Xiaofei;Zhai, Yifan;Zheng, Hao;Wang, Xiaofei;Zheng, Hao;Zhai, Yifan;Zhai, Yifan
关键词：behavior; brain; cell type; insect; single-cell RNA sequencing
-
Improved phyllosphere microbiome composition of tea plant with the application of small peptides in combination with rhamnolipid
作者：Chen, Hao;Song, Yujie;Fan, Kai;Mao, Yilin;Zhang, Jie;Xu, Yang;Yin, Xinyue;Wang, Yu;Wang, Shuangshuang;Ding, Zhaotang;Wang, Hui
关键词：Camellia sinensis (L.) O. Kuntze; Phyllosphere; Small peptides; Surfactants; Rhamnolipid; Microorganisms
