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Illumina high-throughput sequencing for the genome of emerging fowl adenovirus D species and C species simultaneously

文献类型： 外文期刊

作者： Cui, Ning 1 ; Lu, Mei 4 ; Sun, Shiping 1 ; Sun, Shouli 1 ; Xu, Chuantian 1 ; Su, Shuai 3 ; Hrabchenko, Nataliia 1 ; Huang, Qinghua 1 ;

作者机构： 1.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Shandong Key Lab Anim Dis Control & Breeding, Jinan, Peoples R China

2.Key Lab Livestock & Poultry Multi MARA, Jinan, Peoples R China

3.Shandong Agr Univ, Coll Vet Med, Shandong Prov Key Lab Anim Biotechnol & Dis Contro, Tai An, Peoples R China

4.Weifang Engn Vocat Coll, Qingzhou, Peoples R China

关键词： fowl adenovirus; mix infection; high-throughput; genome; evolution

期刊名称：POULTRY SCIENCE （ 影响因子：4.014； 五年影响因子：4.192 ）

ISSN： 0032-5791

年卷期： 2023 年 102 卷 1 期

页码：

收录情况： SCI

摘要： In recent years, clinical cases of inclusion body hepatitis (IBH) and hydropericardium syndrome (HPS) have been emerging and increasing in chicken flocks worldwide. Mixed infections with 2 or more fowl adenovirus (FAdV) serotypes were common in these cases. Herein, we collected a clinical sample that was and HPS symptoms in Shandong province of China and sample contained 2 FAdV strains of D species and C spewith a G+C content of 53.51%, whereas SD1763-2 strain was 43,721 nt in length, with a G+C content of 54.87%. Sequence alignment , phylogenetic analysis revealed that strain SD1763-1 was clustered together with sero-type 2/11 of FAdV-D , SD1763-2 was clustered together with FAdV-4. There is no recombination between the genomes of the 2 viruses of FAdV-D and FAdV-C in the present study. This is the first report of obtaining 2 genomic sequences of FAdV strains simulta-neously by direct use of deep sequencing in one clinical individual chicken sample, which provided direct evi-dence for mixed infections of adenovirus serotypes in the clinic and enriched the genome data to explore the geo-graphic biomarkers and virulence signatures of the genus Aviadenovirus.

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