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Insights into genetic variants within sheep IGF2BP1 and their association with litter size

文献类型： 外文期刊

作者： Liu, Hongfei 1 ; Li, Haixia 1 ; Mao, Cui 2 ; Jiang, Fugui 3 ; Hao, Kunjie 2 ; Han, Xufei 2 ; Lu, Xiaofang 2 ; Pan, Chuany 1 ;

作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, 22 Xinong Rd, Yangling 712100, Shaanxi, Peoples R China

2.Tianjin Aoqun Sheep Ind Res Inst Co, Tianjin 301607, Peoples R China

3.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Shandong Key Lab Anim Dis Control & Breeding, Jinan 250000, Peoples R China

关键词： Sheep; IGF2BP1 gene; InDel; Litter size; Correlation analyses

期刊名称：SMALL RUMINANT RESEARCH （ 影响因子：1.273； 五年影响因子：1.484 ）

ISSN： 0921-4488

年卷期： 2021 年 198 卷

页码：

收录情况： SCI

摘要： Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) plays a crucial role in cellular growth, proliferation, and embryonic development by regulating mRNA stability. IGF2BP1 has been recently found to be located on a new 194.6-kb interval of the fecundity gene FecL. A total of nine insertion/deletion (InDel) variations within IGF2BP1 were identified in 916 adult Australian White sheep, and three were polymorphic: a 5-bp InDel in a downstream region, 9-bp InDel in intron 4, and 15-bp InDel in intron 2. Association analyses indicated that both the 5-bp and 9-bp InDel mutations were significantly associated with litter size at 2nd gestation. The heterozygous genotype (ID) of the 5-bp InDel locus and homozygous insertion genotype (II) of the 9-bp InDel locus were associated with large litter size. Moreover, the combined genotype ID-II of the 5-bp and 9-bp InDel genotypes was identified as the best genotype. These findings will pave the way for future research on markerassisted selection of reproductive traits in sheep breeding.

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