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Regulation of microRNA-33, SREBP and ABCA1 genes in a mouse model of high cholesterol

文献类型： 外文期刊

作者： Zhang, Xianglun 1 ; Zhao, Hongbo 1 ; Sheng, Qingkai 1 ; Liu, Xiaomu 1 ; You, Wei 1 ; Lin, Haichao 1 ; Liu, Guifen 1 ;

作者机构： 1.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Jinan, Peoples R China

2.Shandong Key Lab Anim Dis Control & Breeding, Jinan, Peoples R China

期刊名称：ARCHIVES ANIMAL BREEDING （ 影响因子：0.991； 五年影响因子：1.217 ）

ISSN： 0003-9438

年卷期： 2021 年 64 卷 1 期

页码：

收录情况： SCI

摘要： MicroRNAs are short non-coding RNAs that regulate gene expression. Several microRNAs, useful for coronary artery disease assessment, have previously been identified. MicroRNA-33 is located within SREBP introns and controls cholesterol homeostasis. In order to find the possibility of microRNA-33 as a potential biomarker in high cholesterol disease, we developed a mouse model for coronary heart disease by feeding mice with a high-fat diet. The expression differences of microRNA-33, SREBP and ABCA1 genes in the liver, muscle, and lipid tissues were compared between a high-cholesterol group and control group in mice. The results showed that ABCA1 was up-regulated by high cholesterol conditions in liver, muscle and lipid tissues. SREBP1C was up-regulated by high cholesterol conditions in the liver and lipid tissues and down-regulated by high cholesterol conditions in the muscle tissue. MicroRNA-33 and SREBP2 were down-regulated by high cholesterol conditions in the liver and muscle tissues and up-regulated by high cholesterol conditions in the lipid tissue. Our study suggests that antisense therapeutic targeting of microRNA-33 may be a potential biomarker for cardiovascular disease.

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