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Protocatechuic aldehyde from Salvia miltiorrhiza exhibits an anti-inflammatory effect through inhibiting MAPK signalling pathway

文献类型： 外文期刊

作者： Wu, Shuang 1 ; Wang, Qingyu 2 ; Wang, Jinquan 3 ; Duan, Baoyu 4 ; Tang, Qihe 1 ; Sun, Zhuojian 1 ; Han, Jinlong 5 ; Shan, 1 ;

作者机构： 1.Qingdao Agr Univ, Agr Biopharmaceut Lab, Qingdao 266109, Peoples R China

2.Agr Univ, Coll Vet Med, Natl Ctr Vet Drug Safety Evaluat, Beijing 100089, Peoples R China

3.Xinjiang Agr Univ, Coll Anim Med, Urumqi 830001, Peoples R China

4.Shanghai Univ Med & Hlth Sci, Coll Med Technol, Shanghai 201318, Peoples R China

5.Shandong Acad Agr Sci, Agr Prod Proc Inst, Jinan 250000, Peoples R China

6.China Agr Univ, Coll Vet Med, Ctr Res & Innovat Chinese Tradit Vet Med, Beijing 100089, Peoples R China

关键词： Protocatechuic aldehyde; Salvia miltiorrhiza; Anti-inflammatory; MAPK; NF-κ B

期刊名称：BMC COMPLEMENTARY MEDICINE AND THERAPIES （ 影响因子：-999.999； ）

ISSN：

年卷期： 2020 年 20 卷 1 期

页码：

收录情况： SCI

摘要： Background The aerial parts of Salvia miltiorrhiza, which was considered to be the waste part and discarded during the root harvest, is rich in protocatechuic aldehyde (PAI). This study investigated the health-promoting effects of extracts and PAI from the aerial parts of Salvia miltiorrhiza, including its anti-inflammatory effects and the underlying mechanisms of action in vitro and in vivo. Method Purification of the sample paste of Salvia miltiorrhiza was accomplished using HPLC analysis. TheMTT (Methylthiazolyldiphenyl-tetrazolium bromide) assay was employed to determine the cell viability. The production of inflammatory factors was detected by ELISA assays. The histopathological analysis was used to analyse the lungs and livers of mice treated with PAI. Western blot was performed to reveal the mechanism of PAI in anti-inflammatory. Results The extracts and PAI from the aerial parts of Salvia miltiorrhiza inhibited TNF-alpha, IL-6 production and promoted the production of IL-10 in vivo in mice and in vitro in the macrophage cell line RAW264.7. NF-kappa B and MAPKs kinase phosphorylation were also suppressed by PAI in vivo and in vitro, indicating that PAI exhibited an anti-inflammatory effect. Conclusion These findings suggest that the aerial parts of Salvia miltiorrhiza extract may serve as potential protective agents for inflammatory.

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