Potato virus Y viral protein 6K1 inhibits the interaction between defense proteins during virus infection
文献类型： 外文期刊
作者： Fang, Le 1 ; Geng, Chao 1 ; Wei, Xin-Yu 1 ; Dong, Chen-Chen 1 ; Pang, Ju-Ping 1 ; Yan, Zhi-Yong 1 ; Jiang, Jun 1 ; Tian, Yan-Ping 1 ; Li, Xiang-Dong 1 ;
作者机构： 1.Shandong Agr Univ, Coll Plant Protect, Dept Plant Pathol, Shandong Prov Key Lab Agr Microbiol, Tai An 271018, Shandong, Peoples R China
2.Shandong Acad Agr Sci, Inst Plant Protect, Jinan 250131, Shandong, Peoples R China
期刊名称：PLANT PHYSIOLOGY （ 影响因子：7.4； 五年影响因子：8.7 ）
ISSN： 0032-0889
年卷期： 2023 年
页码：
收录情况： SCI
摘要： 14-3-3 proteins play vital roles in plant defense against various pathogen invasions. To date, how 14-3-3 affects virus infections in plants remains largely unclear. In this study, we found that Nicotiana benthamiana 14-3-3h interacts with TRANSLATIONALLY CONTROLLED TUMOR PROTEIN (TCTP), a susceptibility factor of potato virus Y (PVY). Silencing of Nb14-3-3h facilitates PVY accumulation, whereas overexpression of Nb14-3-3h inhibits PVY replication. The antiviral activities of 3 Nb14-3-3h dimerization defective mutants are significantly decreased, indicating that dimerization of Nb14-3-3h is indispensable for restricting PVY infection. Our results also showed that the mutant Nb14-3-3hE16A, which is capable of dimerizing but not interacting with NbTCTP, has reduced anti-PVY activity; the mutant NbTCTPI65A, which is unable to interact with Nb14-3-3h, facilitates PVY replication compared with the wild-type NbTCTP, indicating that dimeric Nb14-3-3h restricts PVY infection by interacting with NbTCTP and preventing its proviral function. As a counter-defense, PVY 6K1 interferes with the interaction between Nb14-3-3h and NbTCTP by competitively binding to Nb14-3-3h and rescues NbTCTP to promote PVY infection. Our results provide insights into the arms race between plants and potyviruses. The 6K1 protein counters the antiviral role of 14-3-3h to promote potato virus Y infection.
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