A natural substitution of a conserved amino acid in eIF4E confers resistance against multiple potyviruses
文献类型： 外文期刊
作者： Zhou, Ling-Xi 1 ; Tian, Yan-Ping 1 ; Ren, Li-Li 2 ; Yan, Zhi-Yong 1 ; Jiang, Jun 1 ; Shi, Qing-Hua 3 ; Geng, Chao 1 ; Li, Xiang-Dong 1 ;
作者机构： 1.Shandong Agr Univ, Coll Plant Protect, Dept Plant Pathol, Shandong Prov Key Lab Agr Microbiol, Tai An 271018, Shandong, Peoples R China
2.Sci & Technol Res Ctr China Customs, Beijing, Peoples R China
3.Shandong Agr Univ, Coll Hort Sci & Engn, Tai An, Peoples R China
4.Shandong Acad Agr Sci, Inst Plant Protect, Jinan, Peoples R China
关键词： eIF4E; Potyvirus; PRSV-W; PVY; recessive resistance; ZYMV
期刊名称：MOLECULAR PLANT PATHOLOGY （ 影响因子：4.9； 五年影响因子：5.9 ）
ISSN： 1464-6722
年卷期： 2024 年 25 卷 1 期
页码：
收录情况： SCI
摘要： Eukaryotic translation initiation factor 4E (eIF4E), which plays a pivotal role in initiating translation in eukaryotic organisms, is often hijacked by the viral genome-linked protein to facilitate the infection of potyviruses. In this study, we found that the naturally occurring amino acid substitution D71G in eIF4E is widely present in potyvirus-resistant watermelon accessions and disrupts the interaction between watermelon eIF4E and viral genome-linked protein of papaya ringspot virus-watermelon strain, zucchini yellow mosaic virus or watermelon mosaic virus. Multiple sequence alignment and protein modelling showed that the amino acid residue D-71 located in the cap-binding pocket of eIF4E is strictly conserved in many plant species. The mutation D71G in watermelon eIF4E conferred resistance against papaya ringspot virus-watermelon strain and zucchini yellow mosaic virus, and the equivalent mutation D55G in tobacco eIF4E conferred resistance to potato virus Y. Therefore, our finding provides a potential precise target for breeding plants resistant to multiple potyviruses.
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