Potential Pathways Involved in Elaidic Acid Induced Atherosclerosis in Human Umbilical Vein Endothelial Cells
文献类型： 外文期刊
作者： Yu, Huahong 1 ; Li, Xiangmei 1 ; Liang, Zhongshang 1 ; Qiu, Bin 2 ; Li, Siguang 3 ; Luo, Ting 1 ; Li, Jing 1 ; Li, Hongyan 1 ; Deng, Zeyuan 1 ;
作者机构： 1.Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang, Jiangxi, Peoples R China
2.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Jinan 250100, Peoples R China
3.Tongji Univ, Tongji Hosp, Stem Cell Translat Res Ctr, Sch Med, Shanghai 200065, Peoples R China
期刊名称：JOURNAL OF CHEMISTRY （ 影响因子：2.506； 五年影响因子：2.726 ）
ISSN： 2090-9063
年卷期： 2017 年
页码：
收录情况： SCI
摘要： Researches have demonstrated that trans-fatty acids are related to the progression of atherosclerosis, but the underlying mechanism is not clear till now. In the presented study, two-dimensional electrophoresis based proteomics was used to discover the role of elaidic acid in atherosclerosis. In human umbilical vein endothelial cells (HUVEC), twenty-two and twenty-three differentially expressed proteins were identified in low (50 mu mol/L) and high (400 mu mol/L) concentration elaidic acid simulated groups, respectively, comparing with the control group. The expressions of some selected proteins (PSME3, XRCC5, GSTP(1), andGSTO(1)) were validated by qRT-PCR analysis. Western blotting analysis further confirmed that elaidic acid downregulated the expression of PSME3 and XRCC5. Moreover, P53, the downstream protein of PSME3, was further investigated. Results demonstrated that a variety of proteins, many of which were related to oxidative stress, apoptosis, and DNA damage, were involved in the elaidic acid induced atherosclerosis. Furthermore, P53 was demonstrated to regulate the atherosclerosis through cell cycle arrest and apoptosis pathway.
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