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Novel SNPs in the ATP1B2 gene and their associations with milk yield, milk composition and heat-resistance traits in Chinese Holstein cows

文献类型： 外文期刊

作者： Wang, Zeying 1 ; Wang, Genlin 1 ; Huang, Jingmin 2 ; Li, Qiuling 2 ; Wang, Changfa 2 ; Zhong, Jifeng 2 ;

作者机构： 1.Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Jiangsu Prov, Peoples R China

2.Shandong Acad Agr Sci, Dairy Cattle Res Ctr, Jinan 250100, Peoples R China

关键词： Na+-K+-ATPase;Polymorphism;Milk traits;Heat-resistance traits

期刊名称：MOLECULAR BIOLOGY REPORTS （ 影响因子：2.316； 五年影响因子：2.357 ）

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收录情况： SCI

摘要： Genetic association analysis was applied to examine the effect of the Na super(+)/K super(+)-ATPase beta 2 subunit (ATP1B2) gene on rectal temperature, milk traits, K super(+) levels and Na super(+)/K super(+)-ATPase (NKA) activity in the red blood cells of 1001 Chinese Holstein cows under normal and heat-stress conditions. We detected two novel single nucleotide polymorphisms, G2258A and C2833T, in the second and fourth introns, respectively, of ATP1B2. G2258A significantly affected milk fat content (P<0.05) and 305-day milk yield (P<0.01), but not milk protein content. C2833T significantly affected milk protein content (P<0.01) and 305-day milk yield (P<0.05), but not milk fat content. Calculated gene substitution effects suggested that A to G substitution in G2258A, and T to C substitution in C2833T, positively affected milk fat content, 305-day milk yield and somatic cell score, but negatively affected milk protein content. We also detected significant variation in milk fat content, milk protein content, 305-day milk yield and somatic cell scores (P<0.05 or P<0.01) among the nine ATP1B2 haplotypes. Under heat-stress, the C2833T polymorphism was significantly related to rectal temperature (P<0.01), red blood cell K super(+) levels, NKA activity and milk yield (P<0.05). Cows with the TT genotype showed the desirable characteristics of low rectal temperature and red blood cell K super(+), low decline rate in milk yield and red blood cell NKA activity. This study suggests that the ATP1B2 single nucleotide polymorphism C2833T is a genetic marker of heat-resistance traits in Chinese Holstein cows.

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