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The BORDER family of negative transcription elongation factors regulates flowering time in Arabidopsis

文献类型： 外文期刊

作者： Yu, Xuhong 1 ; Martin, Pascal G. P. 1 ; Zhang, Yixiang 2 ; Trinidad, Jonathan C. 2 ; Xu, Feifei 4 ; Huang, Jie 6 ; Thum, Karen E. 1 ; Li, Ke 1 ; Zhao, ShuZhen 7 ; Gu, Yangnan 8 ; Wang, Xingjun 7 ; Michaels, Scott D. 1 ;

作者机构： 1.Indiana Univ, Dept Biol, 915 East Third St, Bloomington, IN 47405 USA

2.Indiana Univ, Dept Chem, Bloomington, IN 47405 USA

3.Indiana Univ, Dept Chem, Lab Biol Mass Spectrometry, Bloomington, IN USA

4.Zhejiang Univ, Inst Nucl Agr Sci, Key Lab Nucl Agr Sci Zhejiang Prov, Zijingang Campus, Hangzhou 310058, Peoples R China

5.Zhejiang Univ, Minist Agr & Rural Affairs, Zijingang Campus, Hangzhou 310058, Peoples R China

6.Indiana Univ, Ctr Genom & Bioinformat, 915 East Third St, Bloomington, IN 47405 USA

7.Shandong Acad Agr Sci, Biotechnol Res Ctr, Shandong Prov Key Lab Crop Genet Improvement Ecol, Jinan 250100, Peoples R China

8.Univ Calif Berkeley, Dept Plant & Microbial Biol, Berkeley, CA 94720 USA

9.Univ Bordeaux, INRAE, UMR BFP, F-33882 Villenave Dornon, France

10.Stoller Enterprises, Houston, TX 77024 USA

期刊名称：CURRENT BIOLOGY （ 影响因子：10.834； 五年影响因子：11.713 ）

ISSN： 0960-9822

年卷期： 2021 年 31 卷 23 期

页码：

收录情况： SCI

摘要： Transcription initiation has long been considered a primary regulatory step in gene expression. Recent work, however, shows that downstream events, such as transcription elongation, can also play important roles.(1-3) A well-characterized example from animals is promoter-proximal pausing, where transcriptionally engaged Pol II accumulates 30-50 bp downstream of the transcription start site (TSS) and is thought to enable rapid gene activation.(2) Plants do not make widespread use of promoter-proximal pausing; however, in a phenomenon known as 30 pausing, a significant increase in Pol II is observed near the transcript end site (TES) of many genes.(4-6) Previous work has shown that 30 pausing is promoted by the BORDER (BDR) family of negative transcription elongation factors. Here we show that BDR proteins play key roles in gene repression. Consistent with BDR proteins acting to slow or pause elongating Pol II, BDR-repressed genes are characterized by high levels of Pol II occupancy, yet low levels of mRNA. The BDR proteins physically interact with FPA,(7) one of approximately two dozen genes collectively referred to as the autonomous floral-promotion pathway,(8) which are necessary for the repression of the flowering time gene FLOWERING LOCUS C (FLC).(9-11) In early-flowering strains, FLC expression is repressed by repressive histone modifications, such as histone H3 lysine 27 trimethylation (H3K27me3), thereby allowing the plants to flower early. These results suggest that the repression of transcription elongation by BDR proteins may allow for the temporary pausing of transcription or facilitate the long-term repression of genes by repressive histone modifications.

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