文献类型： 外文期刊

作者： Li, Zijuan ¹ ; Zhang, Yuyun ¹ ; Ding, Ci-Hang ¹ ; Chen, Yan ⁵ ; Wang, Haoyu ¹ ; Zhang, Jinyu ¹ ; Ying, Songbei ¹ ; Wang, Meiyue ¹ ; Zhang, Rongzhi ⁷ ; Liu, Jinyi ¹ ; Xie, Yilin ¹ ; Tang, Tengfei ¹ ; Diao, Huishan ¹ ; Ye, Luhuan ² ; Zhuang, Yili ² ; Teng, Wan ³ ; Zhang, Bo ¹¹ ; Huang, Lin ¹² ; Tong, Yiping ³ ; Zhang, Wenli ¹³ ; Li, Genying ⁷ ; Benhamed, Moussa ¹⁴ ; Dong, Zhicheng ⁵ ; Gou, Jin-Ying ⁴ ; Zhang, Yijing ¹ ;

作者机构： 1.Fudan Univ, Sch Life Sci, Collaborat Innovat Ctr Genet & Dev, State Key Lab Genet Engn,Inst Plant Biol,Dept Bioc, Shanghai 200438, Peoples R China

2.Chinese Acad Sci, Natl Key Lab Plant Mol Genet, CAS Ctr Excellence Mol Plant Sci, Shanghai Inst Plant Physiol & Ecol,Shanghai Inst B, 300 Fenglin Rd, Shanghai 200032, Peoples R China

3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

4.China Agr Univ, Frontiers Sci Ctr Mol Design Breeding, Beijing, Peoples R China

5.Guangzhou Univ, Guangdong Prov Key Lab Plant Adaptat & Mol Design, Guangzhou Key Lab Crop Gene Editing, Innovat Ctr Mol Genet & Evolut,Sch Life Sci, Guangzhou 510006, Peoples R China

6.Henan Univ, Sch Life Sci, Kaifeng 457000, Henan, Peoples R China

7.Shandong Acad Agr Sci, Crop Res Inst, Jinan, Peoples R China

8.Minist Agr, Key Lab Wheat Biol & Genet Improvement North Yello, Jinan, Peoples R China

9.Natl Engn Res Ctr Wheat & Maize, Jinan, Shandong, Peoples R China

10.Chinese Acad Sci, Inst Genet & Dev Biol, Innovat Acad Seed Design, State Key Lab Plant Cell & Chromosome Engn, Beijing 100101, Peoples R China

11.Chinese Acad Sci, Northwest Inst Plateau Biol, Xining 810008, Peoples R China

12.Sichuan Agr Univ, State Key Lab Crop Gene Explorat & Utilizat Southw, Chengdu 611130, Peoples R China

13.Nanjing Agr Univ, Jiangsu Collaborat Innovat Ctr Modern Crop Prod, State Key Lab Crop Genet & Germplasm Enhancement &, 1 Weigang, Nanjing 210095, Jiangsu, Peoples R China

14.Univ Paris Cite, Inst Plant Sci Paris Saclay IPS2, F-75006 Paris, France

15.Univ Evry, Univ Paris Saclay, Inst Plant Sci Paris Saclay IPS2, CNRS,INRAE, F-91405 Orsay, France

期刊名称：NATURE COMMUNICATIONS （ 影响因子：16.6； 五年影响因子：17.0 ）

ISSN：

年卷期： 2023 年 14 卷 1 期

页码：

收录情况： SCI

摘要： Polyploidization is a major driver of genome diversification and environmental adaptation. However, the merger of different genomes may result in genomic conflicts, raising a major question regarding how genetic diversity is interpreted and regulated to enable environmental plasticity. By analyzing the genome-wide binding of 191 trans-factors in allopolyploid wheat, we identified like heterochromatin protein 1 (LHP1) as a master regulator of subgenome-diversified genes. Transcriptomic and epigenomic analyses of LHP1 mutants reveal its role in buffering the expression of subgenome-diversified defense genes by controlling H3K27me3 homeostasis. Stripe rust infection releases latent subgenomic variations by eliminating H3K27me3-related repression. The simultaneous inactivation of LHP1 homoeologs by CRISPR-Cas9 confers robust stripe rust resistance in wheat seedlings. The conditional repression of subgenome-diversified defenses ensures developmental plasticity to external changes, while also promoting neutral-to-non-neutral selection transitions and adaptive evolution. These findings establish an LHP1-mediated buffering system at the intersection of genotypes, environments, and phenotypes in polyploid wheat. Manipulating the epigenetic buffering capacity offers a tool to harness cryptic subgenomic variations for crop improvement. The regulation of genetic diversity resulting from polyploidization and its impact on environmental adaptability remain unclear. Here, the authors show that LHP1-mediated epigenetic buffering of subgenome diversity and defense responses confers genome plasticity and adaptability in allopolyploid wheat.