A protective mechanism of heat inactivation to enhance Levilactobacillus brevis PDD-2 against alcohol-induced chronic liver disease based on proteomic analysis
文献类型： 外文期刊
作者： Liu, Mingzhen 1 ; Jiang, Xiaoxiao 3 ; Zeng, Xiaoqun 1 ; Guo, Yuxing 3 ; Zhang, Tao 1 ; Fan, Xiankang 1 ; Xu, Jue 1 ; Wu, Zhen 1 ; Pan, Daodong 1 ;
作者机构： 1.Ningbo Univ, State Key Lab Qual & Safety Agroprod, Ningbo 315211, Zhejiang, Peoples R China
2.Ningbo Univ, Coll Food & Pharmaceut Sci, Key Lab Anim Prot Food Proc Technol Zhejiang Prov, Ningbo 315800, Peoples R China
3.Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, Dept Food Sci & Technol, Nanjing 210097, Jiangsu, Peoples R China
4.Inst Agr Prod, Shandong Acad Agr Sci, Jinan 250100, Shandong, Peoples R China
期刊名称：FOOD & FUNCTION （ 影响因子：5.1； 五年影响因子：5.6 ）
ISSN： 2042-6496
年卷期： 2024 年 15 卷 16 期
页码：
收录情况： SCI
摘要： A proteomics-based analysis of the effect of heat inactivation on the alleviation of alcoholic liver disease (ALD) using Levilactobacillus brevis PDD-2 is presented, aimed at exploring the potential and mechanisms of postbiotic elements prepared through heat inactivation in the treatment of ALD. It was found that L. brevis PDD-2 and its postbiotic (heat-inactivated L. brevis PDD-2) alleviate chronic ALD via the gut-liver axis. In particular, heat-inactivated L. brevis PDD-2 significantly increased the relative abundance of Erysipelotrichaceae and better facilitated the oxidative stress balance in the liver. The tandem mass tag (TMT)-based quantitative proteomics technique analyses revealed that heat-inactivated L. brevis PDD-2 was associated with up-regulated expression levels of proteins related to the redox system, cellular metabolism, amino acid and oligopeptide transport, and surface proteins with immunomodulatory capacity. These findings provide a theoretical basis for developing novel therapeutic strategies and lay a solid foundation for further revealing its exhaustive mechanisms.
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