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Effects of fucosylated milk of goat and mouse on Helicobacter pylori binding to Lewis b antigen

文献类型： 外文期刊

作者： Xu, Hong-Tao 1 ; Zhao, Yao-Feng 2 ; Lian, Zheng-Xing 3 ; Fan, Bao-Liang 4 ; Zhao, Zhi-Hui 1 ; Yu, Shu-Yang 1 ; Dai, Yu 1 ;

作者机构： 1.China Agr Univ, State Key Labs Agrobiotechnol, Beijing 100094, Peoples R China

2.Karolinska Inst, Ctr Biotechnol, S-10401 Stockholm, Sweden

3.China Agr Univ, Coll Anim Sci & Technol, Beijing 100094, Peoples R China

4.Shandong Acad Agr Sci, Biotech Res Ctr, Jinan 250100, Shandong, Peoples R China

5.Umea Univ, Dept Odontol & Oral Microbiol, S-90187 Umea, Sweden

期刊名称：WORLD JOURNAL OF GASTROENTEROLOGY （ 影响因子：5.742； 五年影响因子：5.044 ）

ISSN： 1007-9327

年卷期： 2004 年 10 卷 14 期

页码：

收录情况： SCI

摘要： AIM: To evaluate the effects of animal milk containing fucosylated antigens on Helicobacter pylori ( H pylori) binding to Lewis b antigen. METHODS: A mammary gland expression vector containing human alpha 1-3/4-fucosyltransferase cDNA sequences was constructed. Transient expression of human alpha 1-3/4-fucosyltransferase cDNA in goat mammary cell and establishment of transgenic mice were performed. The adhesion inhibitory properties of milk samples were analyzed by using H pylori. RESULTS: Goat milk samples were found to inhibit bacterial binding to Lewis b antigen. The highest inhibition was observed 42 h after injection of the plasmid. The binding activity of H pylori to Lewis b antigen reduced mostly, by 83%, however milk samples from transgenic mice did not inhibit H pylori binding to Lewis b antigen. CONCLUSION: The use of "humanized" animal milk produced by the transgenic introduction of fucosylated antigen can perhaps provide an alternative therapy and preventive measure for H pylori infection.

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