您好，欢迎访问山东省农业科学院文献资源数据库平台

Recombinant Chicken Interferon-alpha Inhibits H9N2 Avian Influenza Virus Replication In Vivo by Oral Administration

文献类型： 外文期刊

作者： Meng, Shanshan 1 ; Yang, Limin 1 ; Xu, Chongfeng 1 ; Qin, Zhuoming 3 ; Xu, Huaiying 3 ; Wang, Youling 3 ; Sun, Lei 1 ; Li 1 ;

作者机构： 1.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China

2.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China

3.Shandong Acad Agr Sci, Inst Poultry Sci, Jinan, Peoples R China

4.Chinese Acad Sci, Inst Microbiol, China Japan Joint Lab Mol Immunol & Mol Microbiol, Beijing 100101, Peoples R China

期刊名称：JOURNAL OF INTERFERON AND CYTOKINE RESEARCH （ 影响因子：2.607； 五年影响因子：2.941 ）

ISSN： 1079-9907

年卷期： 2011 年 31 卷 7 期

页码：

收录情况： SCI

摘要： Chicken interferon-alpha (ChIFN-alpha) has been demonstrated to be an important cytokine in antiviral immunity. However, the preventive or therapeutic effect of ChIFN-alpha as an oral antiviral agent on avian influenza virus (AIV) infection has not been fully clarified in chickens systemically. In the present study, we investigated the anti-H9N2 AIV effect of ChIFN-alpha on a cohort of 7- and 33-day-old specific pathogen-free (SPF) chickens by oral administration. Results showed that both the ChIFN-alpha preventive and therapeutic groups exhibited significantly reduced viral load in trachea when compared with the virus-challenged control group. The therapeutic effect was better than the preventive effect on 7-day-old SPF chickens, which is opposite to 33-day-old SPF chickens. We speculated that T-dependent lymphocyte system of 33-day-old SPF chickens might be easier to be stimulated by ChIFN-alpha than that of 7-day-old SPF chickens. In addition, there was no side effect on the body weight of chickens treated with ChIFN-alpha. We also found that IFN-stimulated genes (ISGs) (2',5'-oligoadenylate synthetase and Mx1) were upregulated in groups treated by ChIFN-alpha and/or virus, indicating that these 2 ISGs not only participated in anti-AIV response in vivo but also could be induced by oral administration of ChIFN-alpha. The present study suggested that ChIFN-alpha could be used as a potential preventive and therapeutic antiviral agent against H9N2 AIV infection by oral administration.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：山东省农业科学院文献资源数据库平台

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台