您好，欢迎访问山东省农业科学院文献资源数据库平台

Novel genetic reassortants in H9N2 influenza A viruses and their diverse pathogenicity to mice

文献类型： 外文期刊

作者： Bi, Yuhai 1 ; Lu, Lu 1 ; Li, Jing 1 ; Yin, Yanbo 3 ; Zhang, Yi 5 ; Gao, Huijie; Qin, Zhuoming 4 ; Zeshan, Basit 1 ; Liu, 1 ;

作者机构： 1.Chinese Acad Sci, Key Lab Pathogen Microbiol & Immunol, Ctr Mol Virol, Inst Microbiol, Beijing 100101, Peoples R China

2.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China

3.Qingdao Agr Univ, Coll Anim Sci & Vet Med, Qingdao 266109, Peoples R China

4.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Jinan 250100, Shandong, Peoples R China

5.China Agr Univ, Coll Vet Med, Key Lab Zoonosis, Minist Agr, Beijing 100193, P

关键词： avian influenza virus;H9N2;reassortant;genotype;pathogenicity

期刊名称：VIROLOGY JOURNAL （ 影响因子：4.099； 五年影响因子：3.719 ）

ISSN： 1743-422X

年卷期： 2011 年 8 卷

页码：

收录情况： SCI

摘要： Background: H9N2 influenza A viruses have undergone extensive reassortments in different host species, and could lead to the epidemics or pandemics with the potential emergence of novel viruses. Methods: To understand the genetic and pathogenic features of early and current circulating H9N2 viruses, 15 representative H9N2 viruses isolated from diseased chickens in northern China between 1998 and 2010 were characterized and compared with all Chinese H9N2 viruses available in the NCBI database. Then, the representative viruses of different genotypes were selected to study the pathogenicity in mice with the aim to investigate the adaptation and the potential pathogenicity of the novel H9N2 reassortants to mammals. Results: Our results demonstrated that most of the 15 isolates were reassortants and generated four novel genotypes (B62-B65), which incorporated the gene segments from Eurasian H9N2 lineage, North American H9N2 branch, and H5N1 viruses. It was noteworthy that the newly identified genotype B65 has been prevalent in China since 2007, and more importantly, different H9N2 influenza viruses displayed a diverse pathogenicity to mice. The isolates of the 2008-2010 epidemic (genotypes B55 and B65) were lowly infectious, while two representative viruses of genotypes B0 and G2 isolated from the late 1990s were highly pathogenic to mice. In addition, Ck/SD/LY-1/08 (genotype 63, containing H5N1-like NP and PA genes) was able to replicate well in mouse lungs with high virus titers but caused mild clinical signs. Conclusion: Several lines of evidence indicated that the H9N2 influenza viruses constantly change their genetics and pathogenicity. Thus, the genetic evolution of H9N2 viruses and their pathogenicity to mammals should be closely monitored to prevent the emergence of novel pandemic viruses.

  • 相关文献

[1]Diversified reassortant H9N2 avian influenza viruses in chicken flocks in northern and eastern China. Huang, Yanyan,Hu, Beixia,Zhang, Xiumei,Huang, Yanyan,Wen, Xintian,Cao, Sanjie,Du, Qijing,Gavrilov, Boris K.,Khan, Mazhar I.. 2010

[2]Lowly pathogenic avian influenza (H9N2) infection in Plateau pika (Ochotona curzoniae), Qinghai Lake, China. Yu, Zhijun,Zhang, Kun,Qin, Chuan,Xia, Xianzhu,Yu, Zhijun,Zhang, Kun,Qin, Chuan,Xia, Xianzhu,Yu, Zhijun,Cheng, Kaihui,Sun, Weiyang,Xin, Yue,Li, Lin,Huang, Jing,Sang, Xiaoyu,Li, Xue,Wang, Tiecheng,Qian, Jun,Gao, Yuwei,Xia, Xianzhu,Cai, Jinshan,Ma, Ruilin,Zhao, Quanbang,Cheng, Kaihui,Huang, Jing,Li, Xue.

[3]PB2-E627K and PA-T97I substitutions enhance polymerase activity and confer a virulent phenotype to an H6N1 avian influenza virus in mice. Cheng, Kaihui,Yu, Zhijun,Sun, Weiyang,Xin, Yue,Huang, Jing,Zhang, Kun,Li, Xue,Yang, Songtao,Wang, Tiecheng,Zheng, Xuexing,Wang, Hualei,Qian, Jun,Gao, Yuwei,Xia, Xianzhu,Cheng, Kaihui,Yu, Zhijun,Qin, Chuan,Xia, Xianzhu,Yu, Zhijun,Qin, Chuan,Xia, Xianzhu,Zhang, Qianyi,Chen, Hualan,Chai, Hongliang,Hua, Yuping.

[4]禽流感病毒识别人受体分子机制及对人感染的再认识. 孟芳,张伟,秦卓明. 2014

[5]MDCK细胞ISG15基因的克隆表达及抗病毒活性分析. 刘爱玲,潘杰,庞运倩,于可响,马秀丽,宋敏训. 2015

[6]近20年中国部分地区鸡源H9N2亚型禽流感病毒HA基因遗传演化及其变异频率. 孟芳,徐怀英,张伟,黄迪海,张再辉,刘霞,常维山,秦卓明. 2016

[7]不同白油佐剂制备的H9N2灭活疫苗在SPF鸡上的免疫效果初试验. 王友令,袁小远,孟凯,徐怀英,张玉霞,李莉,亓丽红,宋敏训,艾武. 2018

[8]1999～2013年山东H9N2亚型禽流感病毒HA基因的演化和HI抗原性差异分析. 张伟,徐怀英,孟芳,马秀丽,刘霞. 2015

[9]2016年山东地区10株H_9N_2亚型禽流感病毒HA基因的遗传演化分析. 邵明辰,王友令. 2018

[10]Comparative analysis of selected innate immune-related genes following infection of immortal DF-1 cells with highly pathogenic (H5N1) and low pathogenic (H9N2) avian influenza viruses. Liu, Ai-ling,Pan, Jie,Li, Yu-feng,Ma, Xiu-Li,Yu, Ke-xiang,Huang, Bing,Song, Min-xun,Qi, Wenbao,Liao, Ming,Li, Feng,Li, Feng.

[11]Multiple adaptive amino acid substitutions increase the virulence of a wild waterfowl-origin reassortant H5N8 avian influenza virus in mice. Yu, Zhijun,Sun, Weiyang,Zhang, Xinghai,Xia, Xianzhu,Gao, Yuwei,Xia, Xianzhu,Gao, Yuwei,Cheng, Kaihui,Xia, Xianzhu,Gao, Yuwei. 2018

[12]Multiple amino acid substitutions involved in the adaptation of H6N1 avian influenza virus in mice. Yu, Zhijun,Qin, Chuan,Xia, Xianzhu,Yu, Zhijun,Qin, Chuan,Xia, Xianzhu,Yu, Zhijun,Cheng, Kaihui,Xin, Yue,Sun, Weiyang,Li, Xue,Huang, Jing,Zhang, Kun,Yang, Songtao,Wang, Tiecheng,Zheng, Xuexing,Wang, Hualei,Qin, Chuan,Xia, Xianzhu,Cheng, Kaihui,Chai, Hongliang.

[13]Rapid acquisition adaptive amino acid substitutions involved in the virulence enhancement of an H1N2 avian influenza virus in mice. Yu, Zhijun,Sun, Weiyang,Zhang, Xinghai,Xia, Xianzhu,Gao, Yuwei,Xia, Xianzhu,Gao, Yuwei,Cheng, Kaihui,Zhao, Chuqi.

[14]H9N2 avian influenza virus-derived natural reassortant H5N2 virus in swan containing the hemagglutinin segment from Eurasian H5 avian influenza virus with an in-frame deletion of four basic residues in the polybasic hemagglutinin cleavage site. Wang, Youling,Yuan, Xiaoyuan,Qi, Lihong,Zhang, Yuxia,Xu, Huaiying,Yang, Jinxing,Ai, Wu,Song, Minxun,Li, Feng,Qi, Wenbao,Liao, Ming,Wang, Dan,Li, Feng,Li, Feng.

[15]Effects of genotypes and plant density on yield, yield components and photosynthesis in Bt transgenic cotton. Dong, HZ,Li, WJ,Tang, W,Li, ZH,Zhang, DM. 2006

[16]Novel SNPs in HSP70A1A gene and the association of polymorphisms with thermo tolerance traits and tissue specific expression in Chinese Holstein cattle. Li, Qiuling,Han, Jianbo,Du, Fanglei,Ju, Zhihua,Huang, Jinming,Wang, Ji,Li, Rongling,Wang, Changfa,Zhong, Jifeng.

[17]Isolation and Analysis of Rice Rf1-Orthologus PPR Genes Co-segregating with Rf3 in Maize. Xu, Xiang-Bo,Liu, Zhan-Xian,Zhang, Deng-Feng,Liu, Ying,Song, Wei-Bin,Li, Jian-Sheng,Dai, Jing-Rui,Xu, Xiang-Bo.

[18]Generation by reverse genetics of an effective attenuated Newcastle disease virus vaccine based on a prevalent highly virulent Chinese strain. Liu, Meng-Meng,Cheng, Jin-Long,Yu, Xiao-Hui,Zhang, Guo-Zhong,Qin, Zhuo-Ming,Tian, Fu-Lin.

[19]Polymorphism of chicken myocyte-specific enhancer-binding factor 2A gene and its association with chicken carcass traits. Zhou, Yan,Liu, Yiping,Zhu, Qing,Zhou, Yan,Jiang, Xiaosong,Du, Huarui,Li, Xiaocheng.

[20]Multiple amino acid substitutions involved in the virulence enhancement of an H3N2 avian influenza A virus isolated from wild waterfowl in mice. Yu, Zhijun,Sun, Weiyang,Zhang, Xinghai,Gao, Yuwei,Xia, Xianzhu,Gao, Yuwei,Xia, Xianzhu,Cheng, Kaihui,Zhao, Chuqi.

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：山东省农业科学院文献资源数据库平台

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台