Sea cucumber intestinal osteotropic peptide promotes tibial fracture healing in osteoporotic mice by promoting glutamine metabolism
文献类型： 外文期刊
作者： Yin, Haowen 1 ; Hur, Sun Jin 3 ; Zhang, Tianqi 1 ; Liu, Hongying 2 ; Yue, Hao 6 ; Wang, Jingfeng 1 ; Zheng, Hongwei 1 ; Xue, Changhu 1 ;
作者机构： 1.Ocean Univ China, Coll Food Sci & Engn, State Key Lab Marine Food Proc & Safety Control, Qingdao 266003, Peoples R China
2.Qingdao Inst Marine Bioresources Nutr & Hlth Innov, Qingdao 266109, Peoples R China
3.Chung Ang Univ, Dept Anim Sci & Technol, Anseong 17546, South Korea
4.Qingdao Langyatai Grp Co Ltd, Qingdao 266500, Peoples R China
5.Shandong Chongzhi Youpin Pet Food Co Ltd, Weifang 261000, Peoples R China
6.Shandong Acad Agr Sci, Inst Food & Nutr Sci & Technol, Jinan 23788, Peoples R China
关键词： Bone health; Glutamine metabolism; Osteoporosis; Osteotropic peptide; Sea cucumber intestine; Tibial fracture
期刊名称：FOOD BIOSCIENCE （ 影响因子：4.8； 五年影响因子：5.1 ）
ISSN： 2212-4292
年卷期： 2024 年 60 卷
页码：
收录情况： SCI
摘要： Sea cucumber (Stichopus japonicus) intestinal high-value-added compounds have not been fully used in sea cucumber processing. Here, the osteotropic effects of sea cucumber intestinal peptides (SCIP) on tibial fractures in osteoporotic mice were investigated. Mice were bilaterally ovariectomized to model osteoporosis and achieved open fracture surgery on the right tibia. The results exhibited that SCIP intervention significantly elevated localized callus and total glutamine levels after fracture in osteoporotic mice. SCIP intervention enhanced the level of acetyl coenzyme A-mediated histone H3 acetylation by up-regulation of the GLS1-GLUD1 axis, thereby significantly promoting the expression of genes specific to chondrocytes. Also, it enhanced aspartate-mediated purine and pyrimidine synthesis by up-regulation of the GLS1-GOT2 axis, thereby significantly promoting the proliferation of chondrocytes. Moreover, it enhanced glutathione-mediated antioxidant damage by upregulating the GLS1-GCLC axis, thereby significantly rescuing the pathological apoptosis of hypertrophic chondrocytes. In conclusion, SCIP promoted chondrocyte generation, proliferation, mineralization, and bone remodeling through glutamine metabolism, thus facilitating fracture healing in osteoporotic mice.
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