Comprehensive Analysis of Differentially Expressed mRNAs, lncRNAs and circRNAs Related to Intramuscular Fat Deposition in Laiwu Pigs
文献类型： 外文期刊
作者： Li, Jingxuan 1 ; Zhao, Xueyan 1 ; Wang, Yanping 1 ; Wang, Jiying 1 ;
作者机构： 1.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Shandong Prov Key Lab Anim Dis Control & Breeding, Jinan 250108, Peoples R China
关键词： message RNA (mRNAs); long noncoding RNAs (lncRNAs); circular RNAs (circRNAs); intramuscular fat (IMF); pigs
期刊名称：GENES （ 影响因子：4.141； 五年影响因子：4.474 ）
ISSN：
年卷期： 2022 年 13 卷 8 期
页码：
收录情况： SCI
摘要： Long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) are important classes of small noncoding RNAs that can regulate numerous biological processes. To understand the role of message RNA (mRNAs, lncRNAs and circRNAs) in the regulation of intramuscular fat (IMF) deposition, in this study the expression profiles of longissimus dorsi (LD) muscle from six Laiwu pigs (three with extremely high and three with extremely low IMF content) were sequenced based on rRNA-depleted library construction. In total, 323 differentially expressed protein-coding genes (DEGs), 180 lncRNAs (DELs) and 105 circRNAs (DECs) were detected between the high IMF and low IMF groups. Functional analysis indicated that most DEGs, and some target genes of DELs, were enriched into GO terms and pathways related to adipogenesis, suggesting their important roles in regulating IMF deposition. In addition, 12 DELs were observed to exhibit a positive relationship with stearoyl-CoA desaturase (SCD), phosphoenolpyruvate carboxykinase 1 (PCK1), and adiponectin (ADIPOQ), suggesting they are highly likely to be the target genes of DELs. Finally, we constructed a source gene-circRNA-miRNA connective network, and some of miRNA of the network have been reported to affect lipid metabolism or adipogenesis. Overall, this work provides a valuable resource for further research and helps to understand the potential functions of lncRNAs and circRNAs in IMF deposition.
- 相关文献
作者其他论文 更多>>
-
Formic acid enhances whole-plant mulberry silage fermentation by boosting lactic acid production and inhibiting harmful bacteria
作者：Hao, Lihong;Jiang, Fugui;Wang, Yanping;Wang, Huaizhong;Hu, Hongmei;You, Wei;Hu, Xin;Cheng, Haijian;Wang, Cheng;Song, Enliang;Hao, Lihong;Jiang, Fugui;Wang, Yanping;Wang, Huaizhong;Hu, Hongmei;You, Wei;Hu, Xin;Cheng, Haijian;Wang, Cheng;Song, Enliang;Song, Enliang
关键词：mulberry; silage; glucose; formic acid; lactic acid bacteria; salts; bacterial community
-
Comparative Analysis of Intestinal Inflammation and Microbiota Dysbiosis of LPS-Challenged Piglets between Different Breeds
作者：Li, Chao;Wang, Yanping;Zhao, Xueyan;Li, Jingxuan;Wang, Huaizhong;Ren, Yifan;Wang, Jiying;Li, Chao;Wang, Yanping;Zhao, Xueyan;Li, Jingxuan;Wang, Huaizhong;Ren, Yifan;Wang, Jiying;Li, Chao;Song, Qinye;Sun, Houwei;Zhu, Xiaodong
关键词：Heigai pigs; intestinal inflammation; jejunum microbiota; lipopolysaccharide; post-weaning diarrhea; 16S rDNA-Seq
-
Identification of a Candidate Gene Regulating Intramuscular Fat Content in Pigs through the Integrative Analysis of Transcriptomics and Proteomics Data
作者：Zhao, Xueyan;Shan, Tizhong;Zhao, Xueyan;Wang, Shouwei;Zheng, Qiankun;Zhao, Xueyan;Jia, Wanli;Wang, Jiying
关键词：pigs; intramuscular fat; TMT; integrativeanalysis; TUSC5
-
Comparative Analysis of Structural Composition and Function of Intestinal Microbiota between Chinese Indigenous Laiwu Pigs and Commercial DLY Pigs
作者：Li, Chao;Song, Qinye;Li, Chao;Zhao, Xueyan;Wang, Yanping;Ren, Yifan;Li, Jingxuan;Wang, Huaizhong;Wang, Jiying;Li, Chao;Zhao, Xueyan;Wang, Yanping;Ren, Yifan;Li, Jingxuan;Wang, Huaizhong;Wang, Jiying;Zhao, Guisheng;Xue, Haipeng
关键词：intestinal microbiota; 16S rRNA sequencing; Laiwu pigs; DLY pigs
-
Single-nucleus and bulk RNA sequencing reveal cellular and transcriptional mechanisms underlying lipid dynamics in high marbled pork
作者：Wang, Liyi;Liu, Shiqi;You, Wenjing;Huang, Yuqin;Zhou, Yanbing;Chen, Wentao;Zhang, Shu;Wang, Yizhen;Shan, Tizhong;Wang, Liyi;Liu, Shiqi;You, Wenjing;Huang, Yuqin;Zhou, Yanbing;Chen, Wentao;Zhang, Shu;Wang, Yizhen;Shan, Tizhong;Wang, Liyi;Liu, Shiqi;You, Wenjing;Huang, Yuqin;Zhou, Yanbing;Chen, Wentao;Zhang, Shu;Wang, Yizhen;Shan, Tizhong;Zhao, Xueyan;Wang, Jiying;Zheng, Qiankun
关键词：
-
E2F1 combined with LINC01004 super-enhancer to promote hepatocellular carcinoma cell proliferation and metastasis
作者：Li, Jingxuan;Wang, Jiying;Wang, Yanping;Zhao, Xueyan;Su, Tao
关键词：lncRNA; Super-enhancer; Hepatocellular carcinoma; E2F1
-
Comparative Transcriptomic Analysis of mRNAs, miRNAs and lncRNAs in the Longissimus dorsi Muscles between Fat-Type and Lean-Type Pigs
作者：Zhang, Jian;Ma, Cai;Wang, Wenlei;Wang, Heng;Jiang, Yunliang;Wang, Jiying
关键词：pig; Longissimus dorsi muscle; transcriptome; mRNA; miRNA; lncRNA; intramuscular fat
