Porcine epidemic diarrhea virus nucleoprotein contributes to HMGB1 transcription and release by interacting with C/EBP-beta
文献类型： 外文期刊
作者： Huan, Chang-chao 1 ; Wang, Hua-xia 1 ; Sheng, Xiang-xiang 1 ; Wang, Rui 1 ; Wang, Xin 1 ; Liao, Ying 2 ; Liu, Qin-fang 2 ;
作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China
2.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China
3.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Jinan 250100, Shandong, Peoples R China
关键词： porcine epidemic diarrhea virus;HMGB1;nucleoprotein;C/EBP-beta
期刊名称：ONCOTARGET （ 影响因子：5.168； 五年影响因子：5.312 ）
ISSN： 1949-2553
年卷期： 2016 年 7 卷 46 期
页码：
收录情况： SCI
摘要： Porcine epidemic diarrhea is a devastating swine enteric disease, which is caused by porcine epidemic diarrhea virus (PEDV) infection. Our studies demonstrated that PEDV infection resulted in the up-regulation of proinflammatory cytokines. Meanwhile, PEDV infection and overexpression of viral nucleoprotein resulted in the acetylation and release of high mobility group box 1 proteins in vitro, an important proinflammatory response mediator, which contributes to the pathogenesis of various inflammatory diseases. Our studies also showed that SIRT1, histone acetyltransferase, and NF-kappa B regulated the acetylation and release of HMGB1. Chromatin immunoprecipitation, dual-luciferase reporter gene assay, and co-immunoprecipitation experiments illustrated that PEDV-N could induce HMGB1 transcription by interacting with C/EBP-beta, which could bind to C/EBP motif in HMGB1 promotor region. Collectively, our data indicate PEDV-N contributes to HMGB1 transcription and the subsequent release/acetylation of HMGB1 during PEDV infection.
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