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The injury of serotonin on intestinal epithelium cell renewal of weaned diarrhoea mice

文献类型： 外文期刊

作者： Dong, Y. 1 ; Yang, C. 1 ; Wang, Z. 1 ; Qin, Z. 2 ; Cao, J. 1 ; Chen, Y. 1 ;

作者机构： 1.China Agr Univ, Coll Anim Med, Lab Vet Anat, Beijing 100193, Peoples R China

2.Shandong Acad Agr Sci, Inst Poultry, Jinan, Peoples R China

关键词： 5-HT;weaned stress mice;intestinal epithelium cell;proliferation;apoptosis

期刊名称：EUROPEAN JOURNAL OF HISTOCHEMISTRY （ 影响因子：3.188； 五年影响因子：2.589 ）

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收录情况： SCI

摘要： Diarrhoea is a common cause of death in children and weaned animals. Recent research has found that serotonin (5-HT) in the gastrointestinal tract plays an important role in regulating growth and the maintenance of mucosa, which protect against diarrhoea. To determine the influence of 5-HT on intestinal epithelium cell renewal under weaned stress diarrhoea, a weaned-stress diarrhoea mouse model was established with senna infusion (15 mL/Kg) via intragastric administration and stress restraint (SR). Mice with an increase in 5-HT were induced by intraperitoneal injection with citalopram hydrobromide (CH, 10 mg/Kg). The results demonstrated that compared with the control animals, diarrhoea appeared in weaned stress mice and the 5-HT content in the small intestine was significantly increased (P<0.05). Further, the caspase-3 cells and cells undergoing apoptosis in the small intestine were significantly increased, but the VH (villus height), V/C (villus height/crypt depth), and PCNA-positive rate significantly decreased. Compared with the control animals, CH increased the intestinal 5-HT content, caspase-3 cells and cells undergoing apoptosis but decreased the VH and V/C. Compared with both control and weaned stress animals, weaned stress animals that were pre-treated with CH showed higher 5-HT concentrations, positive caspase-3 cells and cells undergoing apoptosis but lower VH, V/C and PCNA-positive rate. In vitro, a low concentration of 5-HT inhibit, IEC-6 cell line apoptosis but a higher concentration of 5-HT promoted it. Therefore, weaned stress diarrhoea mice were accompanied by a 5-HT increase in the small intestine and vice versa, and the increase in 5-HT induced by CH caused diarrhoea. In brief, 5-HT and diarrhoea slowed the intestinal epithelium cell renewal and injured the abortion function and mucosal barrier by decreasing VH, V/C and proliferation and increasing epithelium cell apoptosis.

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