您好，欢迎访问山东省农业科学院文献资源数据库平台

Syndecan-4, a PRRSV attachment factor, mediates PRRSV entry through its interaction with EGFR

文献类型： 外文期刊

作者： Wang, Rui 1 ; Wang, Xin 1 ; Ni, Bo 1 ; Huan, Chang-chao 1 ; Wu, Jia-qiang 3 ; Wen, Li-bin 4 ; Liao, Ying 2 ; Tong, Guang- 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Nanjing, Jiangsu, Peoples R China

2.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Beijing, Peoples R China

3.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Beijing, Peoples R China

4.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing, Jiangsu, Peoples R China

关键词： Porcine reproductive and respiratory;syndrome virus;Attachment;Entry;Syndecan-4;EGFR

期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：3.575； 五年影响因子：3.381 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The causative agent of porcine reproductive and respiratory syndrome is the PRRS virus (PRRSV), an enveloped, single-stranded and positive-sense RNA virus. The host factors and mechanisms that are involved in PRRSV entry are still largely unknown. In our present studies, we found that syndecan-4, one of the heparan sulfate proteoglycans, plays a critical role in PRRSV entry, especially in PRRSV attachment. Moreover, EGFR interacts with syndecan-4 in MACR-145 cells and disruption of their interaction impaired PRRSV entry. Furthermore, EGFR inhibitor AG1478 or syndecan-4 derived peptide SSTN87-131 inhibited syndecan-4 endocytosis induced by PRRSV entry. Altogether, syndecan-4, a PRRSV attachment factor, mediated PRRSV entry by interacting with EGFR. (C) 2016 Elsevier Inc. All rights reserved.

  • 相关文献

[1]Efficient porcine reproductive and respiratory syndrome virus entry in MARC-145 cells requires EGFR-PI3K-AKT-LIMK1-COFILIN signaling pathway. Wang, Rui,Wang, Xin,Ni, Bo,Huang, Li,Mao, Xiang,Liao, Ying,Tong, Guang-zhi,Ding, Chan,Mao, Xiang,Wu, Jia-qiang,Wen, Li-bing.

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：山东省农业科学院文献资源数据库平台

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台