文献类型： 外文期刊

作者： Sun, Hong-Zhao ¹ ; Zhao, Shu-Zhen ² ; Ai, Hong-Bin ³ ;

作者机构： 1.Qi Lu Normal Univ, Coll Life Sci, Jinan 250013, Shandong, Peoples R China

2.Shandong Acad Agr Sci, Biotechnol Res Ctr, Jinan 250100, Shandong, Peoples R China

3.Shandong Normal Univ, Coll Life Sci, Key Lab Anim Resistance, Jinan 250014, Shandong, Peoples R China

关键词： gastric motility;L-glutamate;nitric oxide;NMDA receptor;nucleus ambiguus

期刊名称：CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY （ 影响因子：2.273； 五年影响因子：2.45 ）

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收录情况： SCI

摘要： We have previously reported that both L-glutamate (L-Glu) and nitric oxide (NO) modulate gastric motility in the nucleus ambiguus (NA). The aim of this study is to explore the potential correlation between the L-Glu and NO. A latex balloon connected to a pressure transducer was inserted into the pylorus through the fundus of anesthetized male Wistar rats to continuously record changes in gastric smooth muscle contractile curves. Pretreatment with the NO-synthase inhibitor N-nitro-L- arginine methylester (L-NAME) did not completely abolish the inhibitory effect of L-Glu on gastric motility, but intravenous injection of the ganglionic blocker hexamethonium bromide (Hb) did. By using a specific N-methyl-D-aspartic acid (NMDA) receptor antagonist, we blocked the inhibitory effect of the NO-donor sodium nitroprusside (SNP) on gastric motility. These results suggest that microinjections of L-Glu into the NA inhibits gastric motility by activating the cholinergic preganglionic neurons, partially through the NMDA receptor - NO pathway.