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Toxicological Assessment of Chinese Cherry (Cerasus Pseudocerasus L.) Seed Oil

文献类型： 外文期刊

作者： Chen, Qian 1 ; Yin, Yanlei 2 ; Zhu, Chuanhe 1 ; Yu, Guoyong 1 ;

作者机构： 1.Shandong Agr Univ, Coll Food Sci & Engn, Tai An 271018, Shandong, Peoples R China

2.Shandong Inst Pomol, Tai An 271000, Peoples R China

关键词： Chinese cherry (Cerasus pseudocerasus L.) seed oil;toxicology;safety

期刊名称：FOOD SCIENCE AND TECHNOLOGY RESEARCH （ 影响因子：0.668； 五年影响因子：0.895 ）

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收录情况： SCI

摘要： The potential toxic properties and safety of Chinese cherry seed oil (CSO) were investigated by in vitro and in vivo toxicity tests. The acute oral toxicity study revealed no significant difference for the macroscopic results, the mortality and the body weight gain at 4000 mg CSO/kg bw (p＞ 0.05). The results in the bacterial reverse mutation test indicated the doses levels of 100 - 5000 μg/plate did not induce mutations. The mammalian erythrocyte micronucleus test was used to evaluate structural and numerical chromosomal aberrations, compared with the negative control, the results showed no significant difference in micronucleus formation and the ratio of polychromatic erythrocytes and micro nucleated polychromatic erythrocytes at the concentrations of 500 - 2000 mg CSO/kg bw (p ＞ 0.05). According to the mouse sperm abnormality test, CSO has no toxicity on mutagenesis of germ cell at the dietary exposure of 500 - 2000 mg/kg bw. In 28-day oral toxicity test, the food intake, organ weight and the biochemical and hematological parameters of all animals were not significantly different among the tested and the control groups (p ＞ 0.05).

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