Targeted microbiome metabolomics reveals flaxseed oil supplementation regulated the gut microbiota and farnesoid X receptor pathway in high-fat diet mice
文献类型： 外文期刊
作者： Yang, Chen 1 ; Xu, Zhenxia 1 ; Huang, Qingde 1 ; Wang, Xu 2 ; Huang, Fenghong 1 ; Deng, Qianchun 1 ;
作者机构： 1.Chinese Acad Agr Sci, Oil Crops Res Inst, Oil Crops & Lipids Proc Technol Natl & Local Joint, Hubei Key Lab Lipid Chem & Nutr,Key Lab Oilseeds P, Wuhan 430062, Peoples R China
2.Huazhong Agr Univ, Coll Anim Sci & Technol, Wuhan 430070, Peoples R China
3.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Jinan 250100, Peoples R China
关键词： Flaxseed oil; Gut microbiota; Bile acids metabolomics; FXR signaling; High-fat diet
期刊名称：FOOD SCIENCE AND HUMAN WELLNESS （ 影响因子：7.0； 五年影响因子：8.3 ）
ISSN：
年卷期： 2023 年 12 卷 6 期
页码：
收录情况： SCI
摘要： Flaxseed oil (FSO) rich in n-3 polyunsaturated fatty acids (PUFAs) can protect against obesity and insulin resistance, but the underlying mechanism is unknown. An integrative multiomics of the microbiome and targeted metab olomics approach was performed to investigate the possible pathway for flaxseed oil supplementation on reducing serum total cholesterol, triglyceride and epididymal adipose in high-fat diet mice. FSO ameliorated the gut microbial dysbiosis by increasing the community diversity and the abundance of Clostridiales and Ruminococcaceae. These effects were associated with the regulation of bile acid (BAs) in the feces. FSO reduced the concentrations of conjugated BAs, such as cholic acid, tauro-alpha-murocholic acid, and tauro-ursodesoxycholic acid in feces, which in turn inhibit the intestinal farnesoid X receptor (FXR)-fibroblast growth factor (FGF) 15 signaling pathway. Further analysis revealed that FSO activated FXR in the liver and regulated downstream gene expression (SHP, SREBP-1c, and CPT-1a), which promoted lipolysis and inhibited lipogenesis. The results of this study suggest that FSO modulates serum lipid concentrations by regulating the gut microbiota, FXR-FGF15 signaling and BA metabolism. (c) 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- 相关文献
作者其他论文 更多>>
-
Algal oil alleviates antibiotic-induced intestinal inflammation by regulating gut microbiota and repairing intestinal barrier
作者：Zhang, Huimin;Xu, Zhenxia;Chen, Wenchao;Huang, Fenghong;Yang, Chen;Zhang, Huimin;Chen, Shouwen;Huang, Fenghong;Yang, Chen;Wang, Xu
关键词：algal oil; polyunsaturated fatty acids; intestinal barrier; intestinal inflammation; gut microbiota
-
An efficient and robust continuous-flow bioreactor for the enzymatic preparation of phytosterol esters based on hollow lipase microarray
作者：Xu, Liujia;Wang, Jing;Huang, Fenghong;Zheng, Mingming;Huang, Fenghong
关键词：Phytosterol esters; Continuous-flow; Immobilized lipase; Enzymatic esterification; Food additives
-
Encapsulation of Functional Plant Oil by Spray Drying: Physicochemical Characterization and Enhanced Anti-Colitis Activity
作者：Zhang, Hao;Xu, Zhenxia;Tang, Hu;Yang, Chen;Huang, Fenghong;Qiao, Zhixian;Wang, Xu;Huang, Fenghong
关键词：flaxseed oil; encapsulation; oil powder; colitis; gut microbiota
-
DNA-directed coimmobilization of multiple enzymes on organic-inorganic hybrid DNA flowers
作者：Li, Yali;Huang, Fenghong;Li, Yali;Wang, Jing;Huang, Fenghong;Zhang, Yufei;Zheng, Mingming
关键词：DNA-directed immobilization (DDI); rolling circle amplification (RCA); multienzyme coimmobilization; organic-inorganic hydrid DNA flowers (hDFs); colorimetric detection of glucose
-
Development and optimization of spray-dried functional oil microcapsules: Oxidation stability and release kinetics
作者：Yue, Hao;Qiu, Bin;Jia, Min;Huang, Fenghong;Xu, Tongcheng;Liu, Jie;Wang, Jing
关键词：functional oil microcapsules; high amylose corn starch; response surface methodology; spray drying
-
Beneficial effects of flaxseed polysaccharides on metabolic syndrome via gut microbiota in high-fat diet fed mice
作者：Yang, Chen;Xu, Zhenxia;Deng, Qianchun;Huang, Qingde;Huang, Fenghong;Huang, Fenghong;Wang, Xu
关键词：Flaxseed polysaccharides; Metabolic syndrome; Gut microbiota; Akkermansia
-
Flaxseed oligosaccharides alleviate DSS-induced colitis through modulation of gut microbiota and repair of the intestinal barrier in mice
作者：Xu, Zhenxia;Chen, Wenchao;Deng, Qianchun;Huang, Qingde;Yang, Chen;Huang, Fenghong;Wang, Xu;Huang, Fenghong
关键词：
